{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:30:58Z","timestamp":1791235858129,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To compare the efficacy and tolerability of dihydroartemisinin\u2013piperaquine (DHA\u2013PQP) with that of a 3\u2010day regimen of mefloquine and artesunate (MAS3) for the treatment of uncomplicated falciparum malaria in Cambodia.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> Randomized open\u2010label non\u2010inferiority study over 64\u2003days.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Four hundred and sixty\u2010four patients were included in the study. The polymerase chain reaction genotyping\u2010adjusted cure rates on day 63 were 97.5% (95% confidence interval, CI, 93.8\u201399.3) for DHA\u2013PQP and 97.5% (95% CI, 93.8\u201399.3) for MAS3, <jats:italic>P<\/jats:italic>\u2003=\u20031. There were no serious adverse events, but significantly more episodes of vomiting (<jats:italic>P<\/jats:italic>\u2003=\u20030.03), dizziness (<jats:italic>P<\/jats:italic>\u2003=\u20030.002), palpitations (<jats:italic>P<\/jats:italic>\u2003=\u20030.04), and sleep disorders (<jats:italic>P<\/jats:italic>\u2003=\u20030.03) reported in the MAS3 treatment group, consistent with the side\u2010effect profile of mefloquine.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> DHA\u2013PQP was as efficacious as MAS3, but much better tolerated, making it more appropriate for use in a routine programme setting. This highly efficacious, safe and more affordable fixed\u2010dose combination could become the treatment of choice for <jats:italic>Plasmodium falciparum<\/jats:italic> malaria in Cambodia.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2006.01786.x","type":"journal-article","created":{"date-parts":[[2010,8,11]],"date-time":"2010-08-11T22:17:38Z","timestamp":1281565058000},"page":"251-259","source":"Crossref","is-referenced-by-count":52,"title":["A randomized open study to assess the efficacy and tolerability of dihydroartemisinin\u2013piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia"],"prefix":"10.1111","volume":"12","author":[{"given":"B.","family":"Janssens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Van Herp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Goubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Uong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Nong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Socheat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Brockman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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