{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:18:59Z","timestamp":1791231539570,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,9,14]],"date-time":"2007-09-14T00:00:00Z","timestamp":1189728000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2007,9]]},"abstract":"Summary<\/jats:title>\n \n Objectives\u2002<\/jats:bold>\n To identify the main clinical and laboratory features of disseminated histoplasmosis (DH) in human immunodeficiency virus (HIV) patients and compare them with those of HIV patients with other opportunistic diseases.\n <\/jats:p>\n \n Methods\u2002<\/jats:bold>\n Retrospective study of HIV patients comparing the clinical and laboratory data of patients with and without DH. Univariate and multivariate analyses were performed to verify the risk factors related to DH.\n <\/jats:p>\n \n Results\u2002<\/jats:bold>\n In total, 378 HIV patients were included, 164 with DH and 214 with other opportunistic diseases. Acute renal failure, respiratory insufficiency and septic shock were more frequent in DH patients, who also had a higher mortality (32%\n vs<\/jats:italic>\n . 14%,\n P\u2003<\/jats:italic>\n <\n \u2003<\/jats:italic>\n 0.001). Independent risk factors for DH were: acute renal failure [odds ratio (OR) 5.2; 95% confidence interval (CI) 3.2\u20138.5;\n P\u2003<\/jats:italic>\n <\n \u2003<\/jats:italic>\n 0.001], splenomegaly (OR 3.4; 95% CI 1.19\u20139.9;\n P\u2003<\/jats:italic>\n <\n \u2003<\/jats:italic>\n 0.001), respiratory insufficiency (OR 2.7 95% CI 1.5\u20135.0;\n P\u2003<\/jats:italic>\n <\n \u2003<\/jats:italic>\n 0.001), proteinuria (OR 2.7; 95% CI 1.3\u20135.2;\n P\u2003<\/jats:italic>\n =\n \u2003<\/jats:italic>\n 0.03), hypotension (OR 2.5; 95% CI 1.2\u20135.0;\n P\u2003<\/jats:italic>\n =\n \u2003<\/jats:italic>\n 0.008), hepatomegaly (OR 2.4; 95% CI 1.2\u20134.8;\n P\u2003<\/jats:italic>\n =\n \u2003<\/jats:italic>\n 0.01), cutaneous lesions (OR, 1.9; 95% CI 1.0\u20133.3;\n P\u2003<\/jats:italic>\n =\n \u2003<\/jats:italic>\n 0.02) and weight loss (OR 1.8; 95% CI 1.0\u20133.1;\n P\u2003<\/jats:italic>\n =\n \u2003<\/jats:italic>\n 0.03).\n <\/jats:p>\n \n Conclusion\u2002<\/jats:bold>\n Our results suggest that DH is a severe opportunistic disease with high mortality rate, which should be promptly recognized in order to provide early specific treatment.\n <\/jats:p>","DOI":"10.1111\/j.1365-3156.2007.01894.x","type":"journal-article","created":{"date-parts":[[2010,8,11]],"date-time":"2010-08-11T18:08:44Z","timestamp":1281550124000},"page":"1108-1115","source":"Crossref","is-referenced-by-count":68,"title":["Clinical and laboratory features of disseminated histoplasmosis in HIV patients from Brazil"],"prefix":"10.1111","volume":"12","author":[{"given":"Elizabeth F.","family":"Daher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Geraldo B.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando A. 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S.","family":"Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00fasia T.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya A.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julieta C.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f4nia M.H.A.","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oswaldo A.","family":"Guti\u00e9rrez\u2010Adrianz\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm10074611"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199206000-00025"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)90062-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821997000200006"},{"key":"e_1_2_6_6_1","first-page":"1215","volume-title":"Brenner & Rector\u2019s The Kidney","author":"Brady HR","year":"2004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/514556"},{"key":"e_1_2_6_8_1","first-page":"317","article-title":"Serum LDH level as a clue to the diagnosis of histoplasmosis","volume":"12","author":"Butt AA","year":"2002","journal-title":"AIDS Reader"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70224-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/srin.2001.24241"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-86702006000500005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-002-1430-3"},{"key":"e_1_2_6_13_1","article-title":"Revision of the CDC surveillance case definition for the acquired immunodeficiency syndrome","volume":"36","author":"Centers for Disease Control and Prevention","year":"1987","journal-title":"MMWR. 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