{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T20:36:56Z","timestamp":1781987816198,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T00:00:00Z","timestamp":1196985600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To verify the validity of measuring the levels of <jats:italic>Mycobacterium leprae<\/jats:italic>\u2010specific anti\u2010phenolic glycolipid (PGL)\u2010I antibody, neopterin, a product of activated macrophages, and C\u2010reactive protein (CRP), an acute phase protein, in serial serum samples from patients for monitoring the leprosy spectrum and reactions during the course of multi\u2010drug treatment (MDT).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Twenty\u2010five untreated leprosy patients, 15 multi\u2010bacillary (MB) and 10 paucibacillary (PB), participated. Eight patients developed reversal reaction and five developed erythema nodosum leprosum (ENL) during follow\u2010up. The bacterial index (BI) in slit\u2010skin smears was determined at diagnosis and blood samples collected by venipuncture at diagnosis and after 2, 4, 6 and 12\u2003months of MDT. PGL\u2010I antibody and neopterin were measured by enzyme\u2010linked immunosorbent assay, whereas the CRP levels were measured by the latex agglutination method.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The levels of PGL\u2010I antibodies and neopterin were higher in the sera of MB than PB patients, which correlated with the patients\u2019 BI. The serum levels of CRP did not differ significantly between the MB and PB patients. The serum levels of PGL\u2010I and neopterin were no higher in reactional patients than non\u2010reactional patients prone to such reactions. However, ENL patients had higher serum CRP levels than non\u2010reactional MB patients. The serum PGL\u2010I antibody levels declined significantly during MDT, in contrast to neopterin and CRP levels.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Measuring the serum levels of PGL\u2010I antibodies and neopterin appeared to be useful in distinguishing MB from PB patients, whereas monitoring the levels of PGL\u2010I antibodies appeared to be useful in monitoring MB patients on MDT. Measuring serum CRP, although not useful in monitoring the patients, has limited significance in detecting ENL reactional patients.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2007.01951.x","type":"journal-article","created":{"date-parts":[[2010,8,11]],"date-time":"2010-08-11T21:41:56Z","timestamp":1281562916000},"page":"1450-1458","source":"Crossref","is-referenced-by-count":39,"title":["Utility of measuring serum levels of anti\u2010PGL\u2010I antibody, neopterin and C\u2010reactive protein in monitoring leprosy patients during multi\u2010drug treatment and reactions"],"prefix":"10.1111","volume":"12","author":[{"given":"E. A.","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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