{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T08:19:38Z","timestamp":1793953178004,"version":"4.8.0"},"reference-count":22,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective\u2002<\/jats:bold>\n                    To investigate the relationship between avascular osteonecrosis (AVN) and corticosteroid treatment given to patients with severe acute respiratory syndrome (SARS).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods\u2002<\/jats:bold>\n                    Longitudinal study of 71 former SARS patients (mainly health care workers) who had been treated with corticosteroids, with an observation time of 36\u2003months. Magnetic resonance images (MRI) and X\u2010rays of hips, knees, shoulders, ankles and wrists were taken as part of the post\u2010SARS follow\u2010up assessments.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    Thirty\u2010nine per cent developed AVN of the hips within 3\u20134\u2003months after starting treatment. Two more cases of hip necrosis were seen after 1\u2003year and another 11 cases of AVN were diagnosed after 3\u2003years, one with hip necrosis and 10 with necrosis in other joints. In total, 58% of the cohort had developed AVN after 3\u2003years of observation. The sole factor explaining AVN in the hip was the total dose of corticosteroids received.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    The use of corticosteroids in SARS has been debated; opinions conflict about whether the immediate benefits in terms of saving lives compensate for the adverse effects, including AVN.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-3156.2008.02187.x","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T11:15:47Z","timestamp":1244200547000},"page":"79-84","source":"Crossref","is-referenced-by-count":48,"title":["Avascular osteonecrosis after treatment of SARS: a 3\u2010year longitudinal study"],"prefix":"10.1111","volume":"14","author":[{"given":"Hui","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sake J.","family":"De Vlas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010Bao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao\u2010Yang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu\u2010Chun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Hendrik","family":"Richardus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10,7]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1603","article-title":"Consensus for the management of severe acute respiratory syndrome","volume":"116","author":"Anonymous","year":"2003","journal-title":"Chinese Medical Journal [in Chinese]"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2002.33724b"},{"key":"e_1_2_7_4_1","volume-title":"Revised Diagnoses Criterion for Severe Acute Respiratory Syndrome (SARS). May 29 2004","author":"CDC","year":"2004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000137570.37856.ea"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00313020600696231"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92870-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2008.02145.x"},{"key":"e_1_2_7_9_1","first-page":"79","article-title":"Report of the Committee of Staging and Nomenclature","volume":"5","author":"Gardeniers JWM","year":"1993","journal-title":"ARCO News Letter"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc2452"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-2143-y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2351040100"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2003.12.008"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100670200078"},{"key":"e_1_2_7_15_1","first-page":"1348","article-title":"Factors of avascular necrosis of femoral head and osteoporosis in SARS patients\u2019 convalescence","volume":"84","author":"Li YM","year":"2004","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_7_16_1","first-page":"1048","article-title":"Clinical research of correlation between osteonecrosis and steroid","volume":"43","author":"Li ZR","year":"2005","journal-title":"Zhonghua Wai Ke Za Zhi"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/500469"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199205283262206"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.192.3.8058956"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853899309147301"},{"key":"e_1_2_7_21_1","first-page":"1814","article-title":"Report on the investigation of lower extremity osteonecrosis with magnetic resonance imaging in recovered severe acute respiratory syndrome in Guangzhou","volume":"84","author":"Shen J","year":"2004","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_7_22_1","volume-title":"WHO: Case Definitions for Surveillance of Severe Acute Respiratory Syndrome (SARS)","author":"WHO","year":"2003"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3100647"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3156.2008.02187.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3156.2008.02187.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T01:06:44Z","timestamp":1694480804000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3156.2008.02187.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,7]]},"references-count":22,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1111\/j.1365-3156.2008.02187.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3156.2008.02187.x","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,7]]}}}