{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:31:04Z","timestamp":1790235064259,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T00:00:00Z","timestamp":1237420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Artesunate\u2013amodiaquine (AAQ) is efficacious for the treatment of uncomplicated <jats:italic>Plasmodium falciparum<\/jats:italic> malaria in Africa, but little is known about its efficacy in Southeast Asia. We compared the efficacy of dihydroartemisinin\u2013piperaquine (DHP) and AAQ against falciparum malaria in central Vietnam.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Open, randomized clinical trial of 116 patients (36 children aged 6\u201314\u2003years, 80 adults aged 15\u201360\u2003years) were randomly allocated a 3\u2010day course of either DHP (\u223c2.3\u2003mg\/kg dihydroartemisinin plus \u223c18.5\u2003mg\/kg of piperaquine per day) or AAQ (\u223c4.4\u2003mg\/kg of artesunate plus \u223c10.6\u2003mg\/kg of amodiaquine per day). The follow\u2010up period was 42\u2003days.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The two drug combinations were well tolerated by all age groups with no obvious drug associated adverse events. Of the patients who completed 42\u2003days of follow\u2010up, 49 were on DHP (15 children, 34 adults) and 49 were on AAQ (14 children, 35 adults). The 42\u2003day cure rates adjusted for reinfection identified by PCR genotyping for the two groups were similar [100% (49\/49) and 98% (48\/49) for DHP and AAQ, respectively]. With fewer reinfections, DHP appears to possess greater post\u2010treatment prophylactic activity than AAQ.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> AAQ, an inexpensive artemisinin\u2010based combination, could be an additional option to DHP for the treatment of multidrug\u2010resistant falciparum malaria in Vietnam.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2009.02269.x","type":"journal-article","created":{"date-parts":[[2009,3,20]],"date-time":"2009-03-20T15:19:02Z","timestamp":1237562342000},"page":"504-511","source":"Crossref","is-referenced-by-count":22,"title":["Open label randomized comparison of dihydroartemisinin\u2013piperaquine and artesunate\u2013amodiaquine for the treatment of uncomplicated <i>Plasmodium falciparum<\/i> malaria in central Vietnam"],"prefix":"10.1111","volume":"14","author":[{"given":"Nguyen Xuan","family":"Thanh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trieu 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