{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:03:36Z","timestamp":1775174616533,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,11,19]],"date-time":"2010-11-19T00:00:00Z","timestamp":1290124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To report immunovirological outcomes and resistance patterns in adults treated with triple combination antiretroviral therapy (cART) for 4\u2003years in an HIV programme of Phnom Penh, Cambodia.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> It is a longitudinal study and cross\u2010sectional evaluation of adults receiving cART for 4\u2003years. CD4 cell counts and HIV\u20101 RNA were quantified, and resistance patterns were determined. Drug\u2010related toxicity was assessed by clinicians and through laboratory testing.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> After 4\u2003years of cART start, the cumulative probability of retention in care was 0.80 and survival among patients not lost to follow\u2010up was 0.85. A total of 349 patients (98% of eligible) participated in the cross\u2010sectional evaluation. Ninety per cent were receiving first\u2010line therapy, 29% stavudine\u2010 and 58% zidovudine\u2010containing regimens (compared with 94% and 3% at cART initiation). Ninety\u2010three per cent of patients were clinically asymptomatic, and severe lipodystrophy and dyslipidemia were diagnosed in 7.2% and 4.0%, respectively. Good treatment adherence was reported by 83% of patients. Median CD4 T\u2010cell count was 410 cells\/\u03bcl [IQR 290\u2013511], and 90% of patients had &gt;200 cells\/\u03bcl. Only 15 (4%) patients had detectable HIV viral load (eight had &lt;200 CD4 cells\/\u03bcl), five had thymidine analogue mutations, and nine were resistant to two drug classes. In an intention\u2010to\u2010treat analysis, 26.1% (95% CI 22.0\u201330.5) of patients had failed first\u2010line therapy.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> In this Cambodian cohort of adults who started cART at an advanced stage of HIV disease, we observed good clinical and immunovirological outcomes and self\u2010reported treatment adherence at 4\u2003years of therapy.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2010.02689.x","type":"journal-article","created":{"date-parts":[[2010,11,19]],"date-time":"2010-11-19T09:52:30Z","timestamp":1290160350000},"page":"205-213","source":"Crossref","is-referenced-by-count":12,"title":["Immunovirological outcomes and resistance patterns at 4\u2003years of antiretroviral therapy use in HIV\u2010infected patients in Cambodia"],"prefix":"10.1111","volume":"16","author":[{"given":"Mar","family":"Pujades\u2010Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Schramm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leakena","family":"Som","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Nerrienet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prak","family":"Narom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngeth","family":"Chanchhaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Ferradini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suna","family":"Balkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-200112150-00006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200212153-00007"},{"key":"e_1_2_10_4_1","first-page":"114","article-title":"Why is highly active antiretroviral therapy (HAART) not prescribed or discontinued? 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