{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T08:28:31Z","timestamp":1794558511533,"version":"4.9.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To assess the following associations between the second and third trimesters of pregnancy: (i) the intensity of soil\u2010transmitted helminth (STH) infection and haemoglobin\/anaemia, (ii) the effect of mebendazole treatment on the occurrence of STH infection, and (iii) the effect of mebendazole treatment on haemoglobin\/anaemia.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Data originated from a trial of 1042 pregnant women recruited in their second trimester and followed to delivery. Baseline assessments included socio\u2010demographic\/health information from questionnaires, haemoglobin\/anaemia from HemoCue ascertainment of fingerprick blood, and the presence and intensity of STH (<jats:italic>Ascaris lumbricoides<\/jats:italic>, hookworms and <jats:italic>Trichuris trichiura<\/jats:italic>) infections from Kato\u2013Katz examination. All women were given iron supplements; half were randomly allocated to receive single dose 500\u2003mg mebendazole, and half, placebo. Haemoglobin\/anaemia and STH infection status were determined again in the third trimester of pregnancy.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Complete information was available from 935 (89.7%) women. Mebendazole significantly reduced the prevalence and intensity of all three STH infections. Higher intensities of hookworm and <jats:italic>Trichuris<\/jats:italic> infections in the second trimester were associated with a higher risk of anaemia in the third trimester. Overall, women with moderate\/heavy <jats:italic>Trichuris<\/jats:italic> infection were found to be at a higher risk of anaemia; the highest risk was observed among those with moderate\/heavy hookworm co\u2010infection (adjusted OR\u2003=\u20032.77; 95% CI: 1.26, 6.11). Mebendazole treatment did not reduce the risk of anaemia.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Higher intensities of both <jats:italic>Trichuris<\/jats:italic> and hookworm infections are associated with anaemia in pregnancy. The importance of <jats:italic>Trichuris<\/jats:italic> infections during pregnancy requires renewed attention.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2011.02727.x","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T09:06:19Z","timestamp":1296551179000},"page":"531-537","source":"Crossref","is-referenced-by-count":50,"title":["<i>Trichuris<\/i> and hookworm infections associated with anaemia during pregnancy"],"prefix":"10.1111","volume":"16","author":[{"given":"Theresa W.","family":"Gyorkos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas L.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e","family":"Larocque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"Casap\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(05)61008-1"},{"key":"e_1_2_6_3_1","volume-title":"Worldwide Prevalence of Anemia 1993\u20132005: WHO Global Database on Anemia World","author":"de Benoist B","year":"2008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68653-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.04.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000291"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(95)90093-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507795272"},{"key":"e_1_2_6_9_1","first-page":"627","article-title":"Prevalence and consequences of anaemia in pregnancy","volume":"130","author":"Kalaivani K","year":"2009","journal-title":"Indian Journal of Medical Research"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.16.1937"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000681"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2009.09-0091"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/BF03405590","article-title":"Should deworming be included in antenatal packages in hookworm\u2010endemic areas of developing countries?","volume":"97","author":"Larocque R","year":"2006","journal-title":"Canadian Journal of Public Health"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.73.783"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01706.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2010.02.010"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2007.03.017"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2007.09.015"},{"key":"e_1_2_6_19_1","first-page":"14","article-title":"Impact of intestinal helminth infection on anemia and iron status during pregnancy: A community based study in Indonesia","volume":"32","author":"Nurdiati DS","year":"2001","journal-title":"SEA J Trop Med Public Health"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2010.146"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000080938"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(92)90176-D"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.78"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2003.10.002"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2010.02542.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000006867"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(01)90164-6"},{"key":"e_1_2_6_28_1","volume-title":"Guidelines for the Evaluation of Soil\u2010Transmitted Helminthiasis and Schistosomiasis at Community Level. A Guide for Managers of Control Programmes","author":"WHO","year":"1998"},{"key":"e_1_2_6_29_1","volume-title":"Iron Deficiency Anemia: Assessment, Prevention and Control. A Guide for Programme Managers","author":"WHO","year":"2001"},{"key":"e_1_2_6_30_1","volume-title":"The Millennium Development Goals. The Evidence is in: Deworming Helps Meet the Millennium Development Goals","author":"WHO","year":"2005"},{"key":"e_1_2_6_31_1","volume-title":"Preventive Chemotherapy in Human Helminthiasis. Coordinated Use of Anthelminthic Drugs in Control Interventions: A Manual for Health Professionals And Programme Managers","author":"WHO","year":"2006"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3156.2011.02727.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3156.2011.02727.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T17:14:37Z","timestamp":1698772477000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3156.2011.02727.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1111\/j.1365-3156.2011.02727.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3156.2011.02727.x","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}