{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T05:18:15Z","timestamp":1770527895141,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,2,20]],"date-time":"2011-02-20T00:00:00Z","timestamp":1298160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To assess the clinical efficacy of <jats:italic>Lactobacillus sporogenes<\/jats:italic> (<jats:italic>Bacillus coagulans<\/jats:italic>), as probiotic preparation, against dehydrating diarrhoea in children.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Double\u2010blind, randomised, placebo\u2010controlled, hospital\u2010based clinical trial with children aged 6\u201324\u2003months who had diarrhoea with some dehydration. Children received tablets of <jats:italic>L. sporogenes<\/jats:italic> (<jats:italic>B. coagulans<\/jats:italic>) or placebo (control group) and oral rehydration salt solution for correction of initial dehydration as well as maintenance therapy. Duration, frequency, volume of diarrhoea and intake of ORS of two groups were compared as outcome variables.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> One hundred and forty\u2010eight children participated, of whom 78 (Study group) received <jats:italic>L. sporogenes<\/jats:italic> (<jats:italic>B. coagulans<\/jats:italic>) and 70 received placebo (Control group). Differences in recovery rate (<jats:italic>P<\/jats:italic>\u2003=\u20030.2), duration (<jats:italic>P<\/jats:italic>\u2003=\u20030.5), frequency (<jats:italic>P<\/jats:italic>\u2003=\u20030.05), volume (<jats:italic>P<\/jats:italic>\u2003=\u20030.1) of diarrhoea, intake of ORS (<jats:italic>P<\/jats:italic>\u2003=\u20030.2) and other fluids (<jats:italic>P<\/jats:italic>\u2003=\u20030.1) were not significant between both groups. Neither did a subgroup analysis of children who had rotavirus as sole enteropathogens show any significant differences in duration (<jats:italic>P<\/jats:italic>\u2003=\u20030.5), frequency (<jats:italic>P<\/jats:italic>\u2003=\u20030.6), volume (<jats:italic>P<\/jats:italic>\u2003=\u20030.8) of diarrhoea, intake of ORS (<jats:italic>P<\/jats:italic>\u2003=\u20030.8) and other fluids (<jats:italic>P<\/jats:italic>\u2003=\u20030.8) among both groups.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold>  <jats:italic>L. sporogenes<\/jats:italic> (<jats:italic>B. coagulans<\/jats:italic>), as an adjunct to ORS, had no therapeutic impact on management of acute dehydrating diarrhoea of diverse etiology including rotavirus associated diarrhoea in children.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2011.02745.x","type":"journal-article","created":{"date-parts":[[2011,2,21]],"date-time":"2011-02-21T02:53:41Z","timestamp":1298256821000},"page":"555-561","source":"Crossref","is-referenced-by-count":42,"title":["Randomised controlled clinical trial of <i>Lactobacillus sporogenes<\/i> (<i>Bacillus coagulans<\/i>), used as probiotic in clinical practice, on acute watery diarrhoea in children"],"prefix":"10.1111","volume":"16","author":[{"given":"Phalguni","family":"Dutta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Utpala","family":"Mitra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanta","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnan","family":"Rajendran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tushar Kanti","family":"Saha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrinal Kanti","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,20]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"9","article-title":"Biomass production, prevention and characteristics of a strain of Bacillus coagulans as probiotic","volume":"11","author":"Adami A","year":"1993","journal-title":"Microbiology of Elements Nutrition"},{"key":"e_1_2_6_3_1","first-page":"CD003048","article-title":"Probiotics for treating infectious diarrhea","volume":"2","author":"Allen SJ","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_6_4_1","unstructured":"BadmaevV&MajeedM.Lactobacillus sporogenes(Lactospora). 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