{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:56:10Z","timestamp":1793501770243,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,3,21]],"date-time":"2011-03-21T00:00:00Z","timestamp":1300665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective\u2002<\/jats:bold>\n                    To investigate the effects of nutritional supplementation on the outcome and nutritional status of south Indian patients with tuberculosis (TB) with and without human immunodeficiency virus (HIV) coinfection on anti\u2010tuberculous therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Method\u2002<\/jats:bold>\n                    Randomized controlled trial on the effect of a locally prepared cereal\u2013lentil mixture providing 930\u2003kcal and a multivitamin micronutrient supplement during anti\u2010tuberculous therapy in 81 newly diagnosed TB alone and 22\u2003TB\u2013HIV\u2010coinfected patients, among whom 51 received and 52 did not receive the supplement. The primary outcome evaluated at completion of TB therapy was outcome of TB treatment, as classified by the national programme. Secondary outcomes were body composition, compliance and condition on follow\u2010up 1\u2003year after cessation of TB therapy and supplementation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    There was no significant difference in TB outcomes at the end of treatment, but HIV\u2013TB coinfected individuals had four times greater odds of poor outcome than those with TB alone. Among patients with TB, 1\/35 (2.9%) supplemented and 5\/42(12%) of those not supplemented had poor outcomes, while among TB\u2013HIV\u2010coinfected individuals, 4\/13 (31%) supplemented and 3\/7 (42.8%) non\u2010supplemented patients had poor outcomes at the end of treatment, and the differences were more marked after 1\u2003year of follow\u2010up. Although there was some trend of benefit for both TB alone and TB\u2013HIV coinfection, the results were not statistically significant at the end of TB treatment, possibly because of limited sample size.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    Nutritional supplements in patients are a potentially feasible, low\u2010cost intervention, which could impact patients with TB and TB\u2013HIV. The public health importance of these diseases in resource\u2010limited settings suggests the need for large, multi\u2010centre randomized control trials on nutritional supplementation.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-3156.2011.02761.x","type":"journal-article","created":{"date-parts":[[2011,3,21]],"date-time":"2011-03-21T22:32:49Z","timestamp":1300746769000},"page":"699-706","source":"Crossref","is-referenced-by-count":52,"title":["Pilot randomized trial of nutritional supplementation in patients with tuberculosis and HIV\u2013tuberculosis coinfection receiving directly observed short\u2010course chemotherapy for tuberculosis"],"prefix":"10.1111","volume":"16","author":[{"given":"T. D.","family":"Sudarsanam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Mahendri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gerrior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Franciosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gopal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. R.","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Wanke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Muliyil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,21]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"CD006086","article-title":"Nutritional supplements for people being treated for active tuberculosis","volume":"4","author":"Abba K","year":"2008","journal-title":"Cochrane Database Systematic Reviews"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2003936"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040541"},{"key":"e_1_2_6_5_1","volume-title":"Nutritive Value of Indian Foods","author":"Gopalan C","year":"1989"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.45198"},{"key":"e_1_2_6_7_1","volume-title":"Nutrient Requirements & Recommended Dietary Allowances for Indians","author":"Indian Council for Medical Research","year":"1990"},{"key":"e_1_2_6_8_1","first-page":"338","article-title":"Social aspects of patients with pulmonary tuberculosis in Indonesia","volume":"33","author":"Karyadi E","year":"2002","journal-title":"Southeast Asian Journal of Tropical Medicine & Public Health"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/75.4.720"},{"issue":"3","key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"489S","DOI":"10.1093\/ajcn\/64.3.489S","article-title":"Prediction of body cell mass, fat\u2010free mass, and total body water with bioelectrical impedance analysis: effects of race, sex, and disease","volume":"64","author":"Kotler DP","year":"1996","journal-title":"American Journal of Clinical Nutrition"},{"key":"e_1_2_6_11_1","volume-title":"Manual of Socioeconomic Scale","author":"Kuppuswami B","year":"1981"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2009.03.041"},{"key":"e_1_2_6_13_1","first-page":"189","volume-title":"Nutritional Assessment of an Individual","author":"Lukaski H","year":"1989"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4248"},{"key":"e_1_2_6_15_1","volume-title":"Nutritional Aspects of HIV Infection","author":"Miller T","year":"1999"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(99)00003-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.2.460"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2005.01463.x"},{"key":"e_1_2_6_19_1","volume-title":"Technical and Operational Guidelines for Tuberculosis Control","author":"Revised National TB Control Programme","year":"2005"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.11.2843"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/528860"},{"key":"e_1_2_6_22_1","unstructured":"World Health Organization(2004)TB\/HIV Clinical manual. WHO\/HTM\/TB\/2004.329."},{"key":"e_1_2_6_23_1","unstructured":"World Health Organization(2009)Global tuberculosis control: a short update to the 2009 report. WHO\/HTM\/TB\/2009.426."},{"key":"e_1_2_6_24_1","unstructured":"World Health Organization(2010)Guidelines for intensified tuberculosis case\u2010finding and isoniazid preventive therapy for people living with HIV in resource\u2010constrained settings.http:\/\/www.who.int\/hiv\/pub\/tb\/9789241500708\/"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3156.2011.02761.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3156.2011.02761.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T22:17:29Z","timestamp":1698704249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3156.2011.02761.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,21]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1111\/j.1365-3156.2011.02761.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3156.2011.02761.x","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,21]]}}}