{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:08:31Z","timestamp":1768518511472,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,3,29]],"date-time":"2011-03-29T00:00:00Z","timestamp":1301356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To quantify the risk of infection and disease in spouses of tuberculosis patients and the extent to which intervention could reduce the risk in this highly exposed group.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We compared HIV prevalence, TB prevalence and incidence and tuberculin skin test (TST) results in spouses of TB patients and community controls. HIV\u2010positive spouses were offered isoniazid preventive therapy (IPT), and TST was repeated at 6, 12 and 24\u2003months.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> We recruited 148 spouses of smear\u2010positive patients ascertained prospectively and 3% had active TB. We identified 203 spouses of previously diagnosed smear\u2010positive patients, 11 had already had TB, and the rate of TB was 2.4 per 100 person years(py) over 2\u2003years (95% CI 1.15\u20135.09). 116 were found alive and recruited. HIV prevalence was 37% and 39% in the prospective and retrospective spouse groups and 17% in controls. TST was \u226510\u2003mm in 80% of HIV negative and in 57% of HIV\u2010positive spouses ascertained retrospectively; 74% HIV negative and 62% HIV\u2010positive spouses ascertained prospectively, and 48% HIV negative and 26% HIV\u2010positive community controls. Of 54 HIV\u2010positive spouses, 18 completed 6\u2010month IPT. At 2\u2003year follow\u2010up, 87% of surviving spouses had TST \u226510\u2003mm and the rate of TB was 1.1 per 100\u2003py (95% CI 0.34\u20133.29).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Spouses are a high\u2010risk group who should be screened for HIV and active TB. TST prevalence was already high by the time the spouses were approached but further infections were seen to occur. Uptake and adherence to IPT was disappointing, lessening the impact of short\u2010duration therapy.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2011.02763.x","type":"journal-article","created":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T02:27:45Z","timestamp":1301452065000},"page":"811-818","source":"Crossref","is-referenced-by-count":11,"title":["Married to <i>M.\u00a0tuberculosis<\/i>: risk of infection and disease in spouses of smear\u2010positive tuberculosis patients"],"prefix":"10.1111","volume":"16","author":[{"given":"A.","family":"Crampin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kasimba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. J.","family":"Mwaungulu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Dacombe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Floyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Glynn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. E. M.","family":"Fine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Treatment of Tuberculosis","volume":"52","author":"American Thoracic Society, Centers for Disease Control, Infectious Disease Society of America","year":"2003","journal-title":"Morbidity and Mortality Weekly Review Recommendations and Reports"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Targeted tuberculin skin testing and treatment of latent tuberculosis infection","volume":"49","author":"Centres for Disease Control","year":"2000","journal-title":"Morbidity and Mortality Weekly Review Recommendations and Reports"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/506432"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(01)90009-4"},{"key":"e_1_2_6_6_1","first-page":"194","article-title":"Tuberculosis and gender: exploring the patterns in a case control study in Malawi","volume":"8","author":"Crampin AC","year":"2004","journal-title":"International Union against Tuberculosis and Lung Disease"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1205.050789"},{"key":"e_1_2_6_8_1","first-page":"612","article-title":"Assessment and evaluation of contact as a risk factor for tuberculosis in rural Africa","volume":"12","author":"Crampin AC","year":"2008","journal-title":"International Union against Tuberculosis and Lung Disease"},{"key":"e_1_2_6_9_1","first-page":"153","article-title":"What has Karonga taught us? Tuberculosis studied over three decades","volume":"13","author":"Crampin AC","year":"2009","journal-title":"International Union against Tuberculosis and Lung Disease"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60409-6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2005.07.060"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199701000-00016"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1179\/146532806X120291"},{"key":"e_1_2_6_14_1","first-page":"S424","article-title":"Integrated counseling and screening for tuberculosis and HIV among household contacts of tuberculosis patients in an endemic area of HIV infection: Chiang Rai, Thailand","volume":"7","author":"Suggaravetsiri P","year":"2003","journal-title":"International Union against Tuberculosis and Lung Disease"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1997.d01-386.x"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3156.2011.02763.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3156.2011.02763.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T22:31:37Z","timestamp":1698791497000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3156.2011.02763.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,29]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1111\/j.1365-3156.2011.02763.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3156.2011.02763.x","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,29]]}}}