{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:54:04Z","timestamp":1778842444372,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,5,11]],"date-time":"2012-05-11T00:00:00Z","timestamp":1336694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Diabetes is associated with pulmonary tuberculosis (TB), possibly due to impaired immunity, and diabetes may exacerbate the clinical manifestations of TB. Our aim was to assess the role of diabetes in the clinical manifestations of TB.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We studied 1250 patients with pulmonary TB in an urban population in a cross\u2010sectional study in Tanzania. All participants were tested for diabetes and HIV co\u2010infection, and TB culture intensity was assessed. Levels of white blood cells, haemoglobin, acute phase reactants, CD4 count and HIV viral load were measured, and a qualitative morbidity questionnaire was used to identify the prevalence of disease\u2010related symptoms.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Tuberculosis patients with diabetes had a higher neutrophil count (B 0.5\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\u2003cells\/l, 95% CI 0.2; 0.9, <jats:italic>P<\/jats:italic>\u2003=\u20030.001) than non\u2010diabetic TB patients. Serum C\u2010reactive protein (B 18.8\u2003mg\/l, CI 95% 8.2; 29.4, <jats:italic>P<\/jats:italic>\u2003=\u20030.001) and alpha\u20101\u2010acid glycoprotein (B 0.2\u2003g\/l, CI 95% 0.03; 0.3, <jats:italic>P<\/jats:italic>\u2003=\u20030.02) were similarly higher in patients with diabetes. Diabetes did not affect culture intensity or HIV status, but self\u2010reported fever was three times higher among participants with diabetes than in those without diabetes (OR 2.9, CI 95% 1.5; 5.7, <jats:italic>P<\/jats:italic>\u2003=\u20030.002).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Diabetes is associated with small changes in the manifestations of TB, but may have little clinical significance.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2012.03002.x","type":"journal-article","created":{"date-parts":[[2012,5,11]],"date-time":"2012-05-11T11:05:03Z","timestamp":1336734303000},"page":"877-883","source":"Crossref","is-referenced-by-count":19,"title":["The role of diabetes on the clinical manifestations of pulmonary tuberculosis"],"prefix":"10.1111","volume":"17","author":[{"given":"Daniel","family":"Faurholt\u2010Jepsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nyagosya","family":"Range","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"PrayGod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kidola","family":"Jeremiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Faurholt\u2010Jepsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine G.","family":"Aabye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Changalucha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk L.","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Krarup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R.","family":"Witte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aase B.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Friis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/519841"},{"key":"e_1_2_6_3_1","first-page":"307","article-title":"The oral glucose tolerance test in patients with respiratory infections","volume":"54","author":"Ba\u015fo\u011flu OK","year":"1999","journal-title":"Monaldi Archives for Chest Disease"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32832bd7af"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70153-7"},{"key":"e_1_2_6_6_1","first-page":"517","article-title":"Consensus of a group of professional societies and diagnostic companies on guidelines for interim reference ranges for 14 proteins in serum based on the standardization against the IFCC\/BCR\/CAP Reference Material (CRM 470). 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