{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:19:08Z","timestamp":1723058348269},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T00:00:00Z","timestamp":1337731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> The tuberculin skin test (TST) is an important tool in the diagnosis of tuberculosis infection in children. However, the interpretation of TST may be complicated by prior Bacillus Calmette\u2010Guerin (BCG) vaccination. We evaluated the effect of vaccination with BCG on TST reactivity in first\u2010year pupils attending state schools in Antananarivo.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> STs were performed on 376 first\u2010year schoolchildren, aged 6 and 7, attending two state primary schools. The relationships between epidemiological information, BCG status (vaccination, BCG scars) and TST reactivity were assessed to compare TST sensitivity between children with and without BCG vaccination and between those with and without a BCG scar.<\/jats:p><jats:p><jats:bold>Result\u2002<\/jats:bold> The prevalence of positive TST results of \u22655, \u226510 and \u2265 15\u2003mm was 20.2% (76\/376), 18.3% (69\/376) and 11.4% (43\/376), respectively. BCG vaccination was not associated with TST reactivity, whatever the threshold used: \u22655\u2003mm (odds ratio (OR, 1.2; 95% confidence interval (CI), 0.7\u20132.0); \u226510\u2003mm (OR, 0.9; 95% CI, 0.6\u20131.7); \u226515\u2003mm (OR, 0.6; 95% CI, 0.3\u20131.2).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> These results suggest that in Madagascar, a positive TST result indicates TB infection (active or latent) rather than past BCG vaccination. Therefore, high BCG vaccination coverage does not appear to impair the usefulness of the TST as a tool for diagnosing tuberculosis.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2012.03013.x","type":"journal-article","created":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T03:56:25Z","timestamp":1337831785000},"page":"871-876","source":"Crossref","is-referenced-by-count":6,"title":["Tuberculin reactivity in first\u2010year schoolchildren in Madagascar"],"prefix":"10.1111","volume":"17","author":[{"given":"Vaomalala","family":"Raharimanga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rila","family":"Ratovoson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maherisoa","family":"Ratsitorahina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herimanana","family":"Ramarokoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Voahangy","family":"Rasolofo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Talarmin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Richard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200111000-00011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1020-49892003000400003"},{"key":"e_1_2_6_4_1","first-page":"846","article-title":"Tuberculin skin test survey in a pediatric population with high BCG vaccination coverage \u2010\u2010 Botswana, 1996","volume":"46","author":"CDC","year":"1997","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_6_5_1","first-page":"1401","article-title":"Age\u2010specific cut\u2010offs for the tuberculin skin test to detect latent tuberculosis in BCG\u2010vaccinated children","volume":"12","author":"Chan P\u2010C","year":"2008","journal-title":"The International Journal of Tuberculosis and Lung Disease"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.6.2101093"},{"key":"e_1_2_6_7_1","first-page":"773","article-title":"Isoniazid prophylaxis in Alaskan Boarding schools. 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