{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T01:08:22Z","timestamp":1752282502644},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T00:00:00Z","timestamp":1342656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To assess the geographical distribution of melioidosis contamination sources and the association between the location of melioidosis cases and positive sampling sites for <jats:italic>Burkholderia pseudomallei<\/jats:italic> in Taiwan.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Data on the location of melioidosis cases from 2002 to 2011 were combined with the geographical distribution of <jats:italic>B.\u00a0pseudomallei<\/jats:italic> as indicated by the detection of specific flagella gene products measured from 2005 to 2011. Temporal and spatial analyses were used to determine the incidence, cluster shifts and associations between the two datasets.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Melioidosis cases clustered in two \u2018hot\u2010spot\u2019 areas with incidence rates that were significantly higher than in neighbouring towns. The incidence rates in the northern area gradually decreased, while the rates in the southern area increased and were temporally associated with the appearance of <jats:italic>B.\u00a0pseudomallei<\/jats:italic>\u2010specific flagella genes in water samples.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Melioidosis hot\u2010spot areas were present in Taiwan. Water contaminated with <jats:italic>B.\u00a0pseudomallei<\/jats:italic> serves as a potential transmission vehicle and is correlated with an increase in melioidosis cases; this correlation was stronger than that for <jats:italic>B.\u00a0pseudomallei<\/jats:italic>\u2010contaminated soil.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2012.03036.x","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T12:20:33Z","timestamp":1342700433000},"page":"1005-1013","source":"Crossref","is-referenced-by-count":14,"title":["Case cluster shifting and contaminant source as determinants of melioidosis in Taiwan"],"prefix":"10.1111","volume":"17","author":[{"given":"Dajun","family":"Dai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao\u2010Shen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Shih","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.32.5.500"},{"key":"e_1_2_6_3_1","first-page":"95","article-title":"Comparison of 16S RNA, flagella and type III secretion gene primer sets for diagnosis of ara\u2010 Burkholderia pseudomallei in paddy soil","volume":"14","author":"Chen YS","year":"2002","journal-title":"Journal of Biomedical Laboratory Science"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02930965"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01720-09"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.2.383-416.2005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268809991634"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095026880600690X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.65.177"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2004.01328.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000900"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(99)00066-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2010.12.002"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00287-10"},{"key":"e_1_2_6_15_1","first-page":"444","article-title":"Melioidosis in north Queensland 2000\u20102009","volume":"34","author":"Hanna JN","year":"2010","journal-title":"Communicable Diseases Intelligence"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0703.017310"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01036-06"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01038-07"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02931334"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009145"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.10-0038"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2011.00365.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00045600701734224"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(08)70003-8"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01822-10"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.1.232"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00228-07"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1707.101050"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2008.03880.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.60.458"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1385"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.2.923-924.2005"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000496"}],"container-title":["Tropical Medicine &amp; 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