{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T03:05:38Z","timestamp":1767927938057,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,9,14]],"date-time":"2012-09-14T00:00:00Z","timestamp":1347580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To estimate, by neonatal screening, the birth prevalence of congenital toxoplasmosis among live\u2010born infants in Sergipe state, Brazil, and to investigate the clinical features of affected infants.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Dried blood spot specimens obtained from 15\u2003204 neonates were assayed for the presence of anti\u2010<jats:italic>T.\u00a0gondii<\/jats:italic> IgM antibodies. Duplicate retesting was done in infants with positive and borderline results. Confirmatory testing in peripheral blood samples consisted of testing for anti\u2010<jats:italic>T.\u00a0gondii<\/jats:italic> IgG and IgM in infants and mothers. Those with possible congenital toxoplasmosis were evaluated and followed up to a median age of 20\u2003months. Congenital infection was confirmed in the presence of persisting anti\u2010<jats:italic>T.\u00a0gondii<\/jats:italic> IgG antibodies beyond 12\u2003months of age. All infants with confirmed infection were treated with pyrimethamine, sulfadiazine and folinic acid for 1\u2003year.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Fifty\u2010three infants had detectable IgM in dried blood spot specimens. Confirmatory testing was reactive in 39\/50, of which, 38 completed follow\u2010up. Six of 15\u2003204 newborns were diagnosed with congenital toxoplasmosis, resulting in an estimated birth prevalence of four per 10\u2003000 [CI 95% 1.4\u20138.0]. Four infants (67%) showed signs of congenital toxoplasmosis in their first year of life; three (75%) had retinochoroidal scars, and one had cerebral calcifications. Two infants remained asymptomatic until 20\u2003months of age.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The birth prevalence of congenital toxoplasmosis is high in the Brazilian state of Sergipe, with most of the infants showing ocular lesions. Preventive measures are strongly warranted.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2012.03079.x","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T03:07:46Z","timestamp":1347678466000},"page":"1349-1355","source":"Crossref","is-referenced-by-count":12,"title":["Birth prevalence and characteristics of congenital toxoplasmosis in Sergipe, North\u2010east Brazil"],"prefix":"10.1111","volume":"17","author":[{"given":"Ana Dorcas","family":"de Melo Inagaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Gardonyi","family":"Carvalheiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosana","family":"Cipolotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Queiroz","family":"Gurgel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayse Alves","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kariny Souza","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel Melo","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy Ribeiro Resende","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques Leon","family":"Winandy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa M\u00e1rcia","family":"Mussi\u2010Pinhata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095026880400353X"},{"key":"e_1_2_6_3_1","first-page":"15","article-title":"[Toxoplasmose: perfil sorol\u00f3gico de mulheres em idade f\u00e9rtil e gestantes.]","volume":"38","author":"Detanico L","year":"2006","journal-title":"Revista Brasileira de An\u00e1lises Cl\u00ednicas"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268801005775"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822007000200007"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1258\/096914107780154440"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000277"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001195"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406303302604"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1519-38292009000200006"},{"key":"e_1_2_6_11_1","first-page":"532","article-title":"[Seroprevalence of antibodies for toxoplasmosis, rubella, cytomegalovirus, syphilis and HIV among pregnant women in Sergipe]","volume":"42","author":"Inagaki AD","year":"2009","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.77.405"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2007.00869.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01701522"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)11281-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.1.38"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16412-X"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2005.04.011"},{"key":"e_1_2_6_19_1","first-page":"64","article-title":"Estimation of the regional distribution of congenital toxoplasmosis in Brazil from the results of neonatal screening","volume":"20","author":"Neto EC","year":"2010","journal-title":"Scientia Medica"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2007.01.011"},{"key":"e_1_2_6_21_1","first-page":"135","article-title":"Contribution of new techniques for the diagnosis of congenital toxoplasmosis","volume":"47","author":"Robert\u2010Gangneux F","year":"2001","journal-title":"Clinical Laboratory"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762009000300006"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.066514"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60072-5"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.04.042"},{"key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2807\/ese.15.25.19600-en","article-title":"Congenital toxoplasmosis in France in 2007: first results from a national surveillance system","volume":"15","author":"Villena I","year":"2010","journal-title":"Eurosurveillance"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3156.2012.03079.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3156.2012.03079.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T06:59:24Z","timestamp":1698649164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3156.2012.03079.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,14]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1365-3156.2012.03079.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3156.2012.03079.x","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,14]]}}}