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Skin biopsies of 32 horses with a history of urticaria were stained with toluidine blue, a double\u2010labelling method for chymase and tryptase, and immunohistochemistry for immunoglobulin (Ig)E. These horses were compared with horses with pemphigus foliaceus, insect bite hypersensitivity and control horses with healthy skin. Neither formalin fixation time nor biopsy site influenced the staining methods. No chymase\u2010positive cells were found. In all groups of horses, cells staining with toluidine blue and for tryptase and IgE were found in the epidermis and hair follicle papilla and significantly more positively staining cells were observed in the subepidermal dermis compared with the deep dermis. Horses with urticaria had significantly more IgE\u2010bearing cells in the subepidermal dermis than control horses. However, horses with urticaria had significantly fewer toluidine\u2010blue\u2010stained mast cells in both subepidermal and deep dermis compared with the insect bite hypersensitivity and pemphigus foliaceus groups. This study suggests that IgE\u2010mediated reactions play a role in the pathogenesis of urticaria.<\/jats:p>","DOI":"10.1111\/j.1365-3164.2005.00440.x","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T12:29:00Z","timestamp":1113568140000},"page":"94-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Immunoglobulin E\u2010bearing cells and mast cells in skin biopsies of horses with urticaria"],"prefix":"10.1111","volume":"16","author":[{"given":"SILVIA","family":"R\u00dcFENACHT","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ELIANE","family":"MARTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CLAUDIA","family":"VON TSCHARNER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARCUS G.","family":"DOHERR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"URSULA","family":"FORSTER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MONIKA","family":"WELLE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PETRA J.","family":"ROOSJE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.219.1115"},{"key":"e_1_2_6_3_2","first-page":"422","volume-title":"Equine Dermatology","author":"Scott DW","year":"2003"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.78"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.122759"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2000.00222.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00327.x"},{"key":"e_1_2_6_8_2","first-page":"1868","volume-title":"Equine Medicine and Surgery","author":"Logas DB","year":"1999"},{"key":"e_1_2_6_9_2","first-page":"513","volume-title":"Equine Internal Medicine","author":"Moriello KA","year":"1998"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2460\/ajvr.1992.53.02.203","article-title":"Intradermal testing of horses with chronic obstructive pulmonary disease and recurrent urticaria","volume":"53","author":"Evans AG","year":"1992","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0739(17)30332-2"},{"key":"e_1_2_6_12_2","first-page":"212","article-title":"Chronic urticaria in sports horses","volume":"31","author":"Francqueville M","year":"1999","journal-title":"Revue Francaise D\u2019allergologie et D\u2019immunologie Clinique (Paris)"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.1051"},{"key":"e_1_2_6_14_2","first-page":"601","article-title":"Physiopathology of urticaria","volume":"9","author":"Doutre M","year":"1999","journal-title":"European Journal of Dermatology"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-2997(02)00009-2"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70283-0"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.389"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.2746\/042516401776249444"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(97)00096-2"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098589703400104"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00426615"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0959-4493.2001.00264.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(00)00197-8"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200310000-00004"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12547283"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/jmedent\/35.2.120"},{"key":"e_1_2_6_27_2","unstructured":"PascalA ShiebertJ IhrkeP.Seasonality and environmental risk factors for pemphigus foliaceus in animals. 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