{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:43:24Z","timestamp":1790433804196,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T00:00:00Z","timestamp":1129680000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p><jats:bold>Abstract\u2003<\/jats:bold> The efficacy and tolerability of a marbofloxacin\u2010clotrimazole\u2010dexamethasone otic suspension (MCD) was compared with a standard topical treatment using a phase III clinical trial protocol. In a total of 140 dogs with clinical signs of acute or subacute otitis externa, <jats:italic>Staphylococcus<\/jats:italic>, <jats:italic>Pseudomonas<\/jats:italic>, <jats:italic>Enterobacteriaceae<\/jats:italic> and <jats:italic>Malassezia<\/jats:italic> were isolated from samples taken at inclusion to identify the causative pathogen; a further sample was collected in the event of failure or relapse, and from dogs (at day 14) for which <jats:italic>Pseudomonas<\/jats:italic> species had been isolated at inclusion. One group received MCD (10 drops per affected ear) once daily and a second received Surolan\u00ae (containing polymyxin B, miconazole and prednisolone) (5 drops per affected ear), twice daily. Each group received treatment for 7 or 14\u00a0days according to the clinical outcome on day 7. Efficacy and tolerability were evaluated on days 7, 14 and, if necessary, 28 for dogs treated for 14\u00a0days. The trial demonstrated equivalence of both treatments in terms of efficacy, with a cure rate of 58.3% for MCD and 41.2% for Surolan\u00ae. Both medications were equally well tolerated by dogs, but MCD was superior in terms of pain relief, decrease in pus quantity and smell, response rate and investigator's assessment on day 14.<\/jats:p>","DOI":"10.1111\/j.1365-3164.2005.00465.x","type":"journal-article","created":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T16:51:43Z","timestamp":1129740703000},"page":"299-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["A comparative study of two antimicrobial\/anti\u2010inflammatory formulations in the treatment of canine otitis externa"],"prefix":"10.1111","volume":"16","author":[{"given":"SANDRINE","family":"ROUGIER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DANIELA","family":"BORELL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SANDRINE","family":"PHEULPIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FR\u00c9D\u00c9RIQUE","family":"WOEHRL\u00c9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BERNARD","family":"BOISRAM\u00c9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(88)50076-1"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1991.tb00963.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.4102\/jsava.v73i4.581"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/inpract.18.2.66"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/svms.2001.27601"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2003.10.009"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197608000-00009"},{"key":"e_1_2_5_9_2","first-page":"667","volume-title":"The Use of Antibiotics \u2013 a Clinical Review of Antibacterial, Antifungal and Antiviral Drugs","author":"Kucers A","year":"1998"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2003.10.005"},{"key":"e_1_2_5_11_2","first-page":"970","volume-title":"Muller and Kirk's Small Animal Dermatology","author":"Scott SW","year":"1995"},{"key":"e_1_2_5_12_2","first-page":"71","volume-title":"Antibiotiques, Agents Antibact\u00e9riens et Antifongiques.","author":"Bryskier A.","year":"1999"},{"key":"e_1_2_5_13_2","first-page":"315","volume-title":"Antimicrobial Therapy in Veterinary Medicine","author":"Prescott JF","year":"2000"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2003.12.011"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2004.09.004"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/000164801300043208"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1997.tb02987.x"},{"key":"e_1_2_5_18_2","first-page":"393","article-title":"In vitro sensitivity of Malassezia spp. to various antimycotics","volume":"11","author":"Lorenzini R","year":"1985","journal-title":"Drugs Under Experimental and Clinical Research"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0450.1997.tb00964.x"},{"key":"e_1_2_5_20_2","first-page":"585","volume-title":"Kirk's Current Veterinary Therapy XIII. 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