{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:16:31Z","timestamp":1785510991327,"version":"3.56.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T00:00:00Z","timestamp":1299715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The dose of 2% chlorhexidine acetate (2CA; Nolvasan<jats:sup>\u00ae<\/jats:sup> Surgical Scrub; Fort Dodge Animal Health, Fort Dodge, IA, USA) for canine superficial pyoderma was evaluated. The first trial compared three doses (group\u20031, 57\u2003mL\/m<jats:sup>2<\/jats:sup> body surface area; group\u20032, 29\u2003mL\/m<jats:sup>2<\/jats:sup> body surface area; and group\u20033, 19\u2003mL\/m<jats:sup>2<\/jats:sup> body surface area) in a randomized, double\u2010blind, controlled fashion. Twenty\u2010seven dogs with superficial pyoderma were treated with 2CA at the allocated doses every 2\u2003days for 1\u2003week. The owners and investigators subjectively evaluated the dogs, and investigators scored skin lesions, including erythema, papules\/pustules, alopecia and scales, on a 0\u20134 scale. There were no significant differences in response between the treatment groups. The second trial established a practical dose\u2010measuring method for 2CA. Sixty\u2010eight owners were asked to apply 2CA on their palm in an amount corresponding to a Japanese \u00a5500 coin, 26.5\u2003mm in diameter. This yielded an average dose of 0.90\u2003\u00b1\u20030.40\u2003mL. Mathematically, the doses used in groups\u20031, 2 and 3 can be represented as one coin per approximately one\u2010, two\u2010 and three\u2010hand\u2010sized lesions, respectively. The results therefore suggest that owners instructed to apply one coin of the product per two\u2010hand\u2010sized areas of superficial pyoderma would use the range of doses evaluated in this trial.<\/jats:p>","DOI":"10.1111\/j.1365-3164.2011.00968.x","type":"journal-article","created":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T10:24:40Z","timestamp":1299752680000},"page":"449-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Dose assessment of 2% chlorhexidine acetate for canine superficial pyoderma"],"prefix":"10.1111","volume":"22","author":[{"given":"Nobuo","family":"Murayama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Terada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mio","family":"Okuaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,10]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"277","volume-title":"Muller and Kirk\u2019s Small Animal Dermatology","author":"Scott DW","year":"2001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00360-07"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1996.tb00242.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00635.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00898.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.2736\/jjvd.12.1"},{"key":"e_1_2_6_8_2","first-page":"10","article-title":"Atopiseihihuen no shojo to chiryo","volume":"11","author":"Furue M","year":"2005","journal-title":"Chozai to Joho"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2736\/jjvd.14.71"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1265\/jjh.23.443"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90204-3"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3164.2011.00968.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3164.2011.00968.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T08:42:42Z","timestamp":1697272962000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3164.2011.00968.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,10]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1111\/j.1365-3164.2011.00968.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3164.2011.00968.x","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,10]]},"assertion":[{"value":"2011-03-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}