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Ten healthy adult dogs were included in the study. A single dose of terbinafine (30\u201335\u2003mg\/kg) was administered orally, and blood samples were periodically collected over a 24\u2003h period during which dogs were monitored for adverse effects. Two of 10 dogs developed transient ocular changes. A high\u2010performance liquid chromatography assay was developed and used to determine plasma terbinafine concentrations. Pharmacokinetic analysis was performed using PK Solutions<jats:sup>\u00ae<\/jats:sup>computer software. Area under the curve (AUC) from time 0 to 24\u2003h was 15.4\u2003\u03bcg\u00b7h\/mL (range 5\u201327), maximal plasma concentration (<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>) was 3.5\u2003\u03bcg\/mL (range 3\u20134.9\u2003\u03bcg\/mL) and time to<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>(<jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub>) was 3.6\u2003h (range 2\u20136\u2003h). The time above minimal inhibitory concentration (<jats:italic>T<\/jats:italic>\u2003&gt;\u2003MIC) as well as AUC\/MIC was calculated for important invasive fungal pathogens and dermatophytes. The<jats:italic>T<\/jats:italic>\u2003&gt;\u2003MIC was 17\u201318\u2003h for<jats:italic>Blastomyces dermatitidis<\/jats:italic>,<jats:italic>Histoplasma capsulatum<\/jats:italic>and dermatophytes (<jats:italic>Microsporum<\/jats:italic>spp. and<jats:italic>Trichophyton mentagrophytes<\/jats:italic>), while the MIC for<jats:italic>Sporothrix schenckii<\/jats:italic>and<jats:italic>Coccidioides immitis<\/jats:italic>was exceeded for 9.5\u201311\u2003h. The AUC\/MIC values ranged from 9 to 13\u2003\u03bcg\u2003h\/mL for these fungi. Our results provide evidence supporting the use of terbinafine as an oral therapeutic agent for treating systemic and subcutaneous mycoses in dogs.<\/jats:p>","DOI":"10.1111\/j.1365-3164.2011.00985.x","type":"journal-article","created":{"date-parts":[[2011,5,20]],"date-time":"2011-05-20T22:23:56Z","timestamp":1305930236000},"page":"528-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Terbinafine pharmacokinetics after single dose oral administration in the dog"],"prefix":"10.1111","volume":"22","author":[{"given":"Mary R.","family":"Sakai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth R.","family":"May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula 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