{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:25:39Z","timestamp":1760549139915,"version":"3.38.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study evaluated the efficacy of a 0.0584% hydrocortisone aceponate (HCA) spray (Cortavance<jats:sup>\u00ae<\/jats:sup>; Virbac SA) in 10 cats with presumed allergic dermatitis. The cats initially received two sprays\/100\u2003cm<jats:sup>2<\/jats:sup>of skin once daily. Clinical lesions (a Feline Dermatitis Extent and Severity Index; FeDESI), pruritus (10\u2003cm visual analog scale with grade descriptors) and owner assessments of efficacy, tolerance and ease of use (from 1\u2003=\u2003very poor to 5\u2003=\u2003excellent) were assessed every 14\u2003days. The frequency of treatment was reduced after day\u200328 in cats with a &gt;50% reduction in FeDESI and pruritus scores. One cat was lost to follow up at day\u200328 and two at day\u200342. Intention\u2010to\u2010treat data were analysed. The FeDESI [mean (SD): day\u20030, 42.2 (15.7) and day\u200356, 9.9 (11.7);<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001] and pruritus scores [day\u20030, 61.2\u2003mm (20.1) and day\u200356, 14.6\u2003mm (16.1);<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001] significantly decreased throughout the trial. The owner scores for tolerance [median (range): day\u200314, 4 (1\u20135) and day\u200356, 4 (3\u20135);<jats:italic>P<\/jats:italic>\u2003=\u20030.003] and ease of administration [day\u200314, 3 (2\u20135) and day\u200356, 4 (2\u20135);<jats:italic>P<\/jats:italic>\u2003=\u20030.02] significantly increased during the trial, but there was no significant change in efficacy scores [day\u200314, 4 (3\u20135) and day\u200356, 4 (2\u20135);<jats:italic>P<\/jats:italic>\u2003=\u20030.5]. There were no adverse effects attributable to the HCA spray, no significant changes in weight [mean (SD): day\u20030, 5.0\u2003kg (1.4) and day\u200356, 5.0\u2003kg (1.6);<jats:italic>P<\/jats:italic>\u2003=\u20030.51] and no significant changes in haematology, biochemistry or urinalysis (<jats:italic>n<\/jats:italic>\u2003=\u20034). Six cats required every\u2010other\u2010day treatment and four required daily treatment. In conclusion, HCA spray appeared to be effective and safe in these cats, although it is not licensed for use in this species.<\/jats:p>","DOI":"10.1111\/j.1365-3164.2011.00993.x","type":"journal-article","created":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T09:43:57Z","timestamp":1309513437000},"page":"11","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy of a 0.0584% hydrocortisone aceponate spray in presumed feline allergic dermatitis: an open label pilot study"],"prefix":"10.1111","volume":"23","author":[{"given":"Vanessa","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M.","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil 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