{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T03:26:28Z","timestamp":1770348388762,"version":"3.49.0"},"reference-count":62,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T00:00:00Z","timestamp":1328572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>The aim of this review is to consider systemic therapy options for meticillin\u2010resistant<jats:italic>Staphylococcus pseudintermedius<\/jats:italic>(MRSP).<\/jats:p><jats:p>Infections caused by MRSP in small animals \u2013 particularly dogs \u2013 have been frustrating veterinarians in recent years. After a susceptibility test is performed, veterinarians are left to select from drugs that have not been frequently encountered on a susceptibility report. Some of these are old drugs that have not been used regularly by veterinary dermatologists.<\/jats:p><jats:p>As MRSP is, by definition, resistant to all \u03b2\u2010lactam antibiotics, including cephalosporins, penicillins and amoxicillin\u2013clavulanate combinations, the \u03b2\u2010lactam drugs are not an option for systemic treatment. As most MRSPs are multidrug resistant, familiar drugs, such as trimethoprim\u2013sulfonamides, fluoroquinolones, macrolides and lincosamides (clindamycin), are also not usually an option for treatment.<\/jats:p><jats:p>Therefore, veterinarians are left with drugs such as rifampicin, chloramphenicol, tetracyclines, aminoglycosides and vancomycin to choose from on the basis of an<jats:italic>in vitro<\/jats:italic>susceptibility test. Some of these drugs were originally approved over 50\u2003years ago and may not be familiar to some veterinarians. Each of these drugs possesses unique properties and has particular advantages and disadvantages. Veterinarians should be particularly aware of the adverse effects, limitations and precautions when using these drugs.<\/jats:p><jats:p>New drugs also have been developed for meticillin\u2010resistant<jats:italic>Staphylococcus aureus<\/jats:italic>in humans. These include linezolid, ceftaroline, daptomycin and tigecycline. Although these drugs are very infrequently \u2013 if ever \u2013 considered for veterinary use, the properties of these drugs should also be known to veterinary dermatologists.<\/jats:p>","DOI":"10.1111\/j.1365-3164.2011.01030.x","type":"journal-article","created":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T19:47:55Z","timestamp":1328644075000},"page":"352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Selection of antibiotics for meticillin\u2010resistant<i>Staphylococcus pseudintermedius<\/i>: time to revisit some old drugs?"],"prefix":"10.1111","volume":"23","author":[{"given":"Mark 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