{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:06:47Z","timestamp":1788307607994,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T00:00:00Z","timestamp":1330041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:bold>Background\u2002\u2013\u2002<\/jats:bold>The prevalence of meticillin\u2010 and multidrug\u2010resistant<jats:italic>Staphylococcus pseudintermedius<\/jats:italic>(MRSP) in canine pyoderma has been increasing in recent years; thus, treatment of these cases has become challenging.<\/jats:p><jats:p><jats:bold>Hypothesis\/Objectives\u2002\u2013\u2002<\/jats:bold>To compare treatment outcome (clinical resolution and treatment duration), adverse effects of medication, and concurrent diseases and medications in dogs with meticillin\u2010susceptible<jats:italic>S.\u00a0pseudintermedius<\/jats:italic>(MSSP) and MRSP pyoderma.<\/jats:p><jats:p><jats:bold>Animals\/Methods\u2002\u2013\u2002<\/jats:bold>Medical records were reviewed retrospectively, and 123 MSSP and 93 MRSP clinical cases between January 2008 and April 2010 were included.<\/jats:p><jats:p><jats:bold>Results\u2002\u2013\u2002<\/jats:bold>In MSSP infections, cefalexin and cefpodoxime were the most commonly prescribed antimicrobials, accounting for 43.2 and 34.4% of cases, respectively. In MRSP infections, chloramphenicol and doxycycline were most commonly prescribed, accounting for 52.6 and 14.4% of cases, respectively. Adverse effects were reported in seven MSSP and 31 MRSP cases. The most commonly reported adverse effects were gastrointestinal, prompting antibiotic discontinuation in three MSSP and 20 MRSP cases. Chloramphenicol was associated with the highest incidence of adverse reactions (27 of 51 cases). Of 164 cases with follow up, 43 of 88 MSSP infections and 29 of 76 MRSP infections achieved complete clinical resolution at the first recheck examination. Three MSSP and seven MRSP cases failed to improve or resolve at subsequent visits assessed at 3\u20134\u2003week intervals.<\/jats:p><jats:p><jats:bold>Conclusions and clinical importance\u2002\u2013\u2002<\/jats:bold>Results from this study showed that the majority of pyodermas resolved regardless of meticillin susceptibility. Although some cases of MRSP pyoderma took longer to treat, this is likely to be because of chronicity and not the organism. In addition, adverse effects were frequently associated with chloramphenicol administration.<\/jats:p>","DOI":"10.1111\/j.1365-3164.2012.01034.x","type":"journal-article","created":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T19:06:24Z","timestamp":1330110384000},"page":"361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Treatment outcome of dogs with meticillin\u2010resistant and meticillin\u2010susceptible<i>Staphylococcus pseudintermedius<\/i>pyoderma"],"prefix":"10.1111","volume":"23","author":[{"given":"Jacqueline","family":"Bryan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A.","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barton W.","family":"Rohrbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Burgette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine L.","family":"Cain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bemis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,24]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01150-07"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02193-06"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.19.5.610-615.1984"},{"key":"e_1_2_7_5_2","first-page":"277","volume-title":"Muller and Kirk\u2019s Small Animal Dermatology","author":"Scott DW","year":"2001"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00828.x"},{"key":"e_1_2_7_7_2","first-page":"254","article-title":"Microbial diseases secondary to allergic skin disease \u2013 clinical significance and control","volume":"19","author":"Lloyd DH","year":"2009","journal-title":"Eur J Companion Anim"},{"key":"e_1_2_7_8_2","first-page":"280","article-title":"Meticillin\u2010resistant staphylococci in companion animals","volume":"18","author":"Nuttall T","year":"2008","journal-title":"Eur J Companion Anim"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.230.2.221"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2004.65.1265"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.4.781"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02255-07"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq078"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2011.02.002"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0450.2004.00816.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2009.01.011"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.2736\/jjvd.14.135"},{"key":"e_1_2_7_18_2","first-page":"390","volume-title":"Manual of Clinical Microbiology","author":"Bannerman TL","year":"2007"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2011.04.019"},{"key":"e_1_2_7_20_2","unstructured":"Clinical and Laboratory Standards Institute (CLSI).Performance Standard for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated from Animals; Approved Standard \u2013 3rd edition. 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