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Topical antimicrobials may be used as adjunctive therapy to systemic treatment or as sole therapy instead of systemic treatment.<\/jats:p><jats:p><jats:bold>Objective \u2013\u2002<\/jats:bold>This literature review evaluated studies on topical antimicrobial treatment of skin infections.<\/jats:p><jats:p><jats:bold>Methods \u2013\u2002<\/jats:bold><jats:italic>In vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>studies evaluating topical antimicrobial agents were identified using a number of electronic and manual searches of textbooks and articles. Studies were evaluated, and the evidence for or against the use of the topical agents was extracted.<\/jats:p><jats:p><jats:bold>Results \u2013\u2002<\/jats:bold>There is good evidence for the efficacy of chlorhexidine and, to a lesser degree, benzoyl peroxide in canine bacterial skin infections. There is limited evidence for the efficacy of silver sulfadiazine and medical honey against bacterial skin infections in the dog, and for the efficacy of hydrogen peroxide and stannous fluoride in the horse. Good evidence supports the use of a combination of chlorhexidine and miconazole in dogs with cutaneous<jats:italic>Malassezia<\/jats:italic>infections. There is insufficient evidence to recommend any other topical therapy for use in cutaneous infections.<\/jats:p><jats:p><jats:bold>Conclusions and clinical importance \u2013\u2002<\/jats:bold>Although many antimicrobial topicals are marketed in veterinary dermatology, the efficacy has been reported for only a minority of agents. 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