{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:41:45Z","timestamp":1776436905197,"version":"3.51.2"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T00:00:00Z","timestamp":1340582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p><jats:bold>Background\u2002\u2013\u2002<\/jats:bold>Glucocorticoids as sole therapy for pemphigus foliaceus (PF) in cats are not always successful, and it is common to need additional immunomodulating agents to manage the disease.<\/jats:p><jats:p><jats:bold>Hypothesis\/Objectives\u2002\u2013\u2002<\/jats:bold>This retrospective study evaluated the use of modified ciclosporin as an adjuvant or sole immunomodulating drug in cats with PF and compared their response to PF cats managed with chlorambucil.<\/jats:p><jats:p><jats:bold>Animals\u2002\u2013\u2002<\/jats:bold>Fifteen client\u2010owned cats diagnosed with PF that received ciclosporin and\/or chlorambucil as part of their treatment and had adequate follow\u2010up to assess treatment response were evaluated.<\/jats:p><jats:p><jats:bold>Methods\u2002\u2013\u2002<\/jats:bold>Records were reviewed from feline PF patients presented between the years of 1999 and 2009. Cats were divided into two treatment groups: those treated with ciclosporin and those treated with chlorambucil. Most cats in both groups also received concurrent systemic glucocorticoids. Each group contained six patients. Three cats were treated with both medications and are discussed separately. Time to disease remission, remission\u2010inducing glucocorticoid dose, maintenance or final glucocorticoid dose, disease response and adverse effects were assessed.<\/jats:p><jats:p><jats:bold>Results\u2002\u2013\u2002<\/jats:bold>There was no significant difference in remission times or disease response between groups. All six patients maintained with ciclosporin for PF management were weaned off systemic glucocorticoids, while glucocorticoid therapy was stopped in only one of the six cats receiving chlorambucil.<\/jats:p><jats:p><jats:bold>Conclusions and clinical importance\u2002\u2013\u2002<\/jats:bold>Modified ciclosporin is effective in the management of feline pemphigus foliaceus and is glucocorticoid sparing.<\/jats:p>","DOI":"10.1111\/j.1365-3164.2012.01069.x","type":"journal-article","created":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T14:40:17Z","timestamp":1340635217000},"page":"403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Use of modified ciclosporin in the management of feline pemphigus foliaceus: a retrospective analysis"],"prefix":"10.1111","volume":"23","author":[{"given":"Katherine E.","family":"Irwin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin M.","family":"Beale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie A.","family":"Fadok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7216-7618-0.50013-4"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00360.x"},{"key":"e_1_2_5_4_2","first-page":"433","article-title":"Pemphigus diseases in the feline: seven case reports and discussion","volume":"18","author":"Manning TO","year":"1982","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2006.00540.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.2460\/ajvr.1992.53.7.1236","article-title":"Systemic toxicosis associated with azathioprine administration in domestic cats","volume":"53","author":"Beale KM","year":"1992","journal-title":"Am J Vet Res"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2007.00137.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.152.25.768"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00376.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2460\/javma.1992.201.02.285","article-title":"Renal transplantation for treatment of end\u2010stage renal failure in cats","volume":"201","author":"Gregory CR","year":"1992","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2005.00489.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2003.00317.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2006.00514.x"},{"key":"e_1_2_5_14_2","first-page":"377","article-title":"Clinical evaluation of cyclosporin in animal models of cutaneous immune\u2010mediated disease and epitheliotropic lymphoma","volume":"25","author":"Rosenkrantz WS","year":"1989","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.152.2.53"},{"key":"e_1_2_5_16_2","first-page":"192","article-title":"Cyclosporine, ketoconazole and azathioprine combination therapy in three cases of refractory canine pemphigus foliaceus","volume":"17","author":"Rosenkrantz W","year":"2007","journal-title":"Vet Dermatol"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2003.00347.x"},{"key":"e_1_2_5_18_2","volume-title":"Plumb\u2019s Veterinary Drug Handbook","author":"Plumb DC","year":"2008"},{"key":"e_1_2_5_19_2","first-page":"5","article-title":"Chlorambucil: effective therapeutic options for the treatment of feline immune\u2010mediated dermatoses","volume":"20","author":"Rhodes KH","year":"1992","journal-title":"Feline Pract"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.70.1011"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.69.887"},{"key":"e_1_2_5_22_2","first-page":"836","article-title":"Physiological effects and pharmacologic considerations of glucocorticoids","volume":"97","author":"Bondy PJ","year":"2002","journal-title":"Vet Med"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00717.x"},{"key":"e_1_2_5_24_2","unstructured":"Atopica for cats (cyclosporine oral solution USP) Modified. Freedom of Information Summary \u2013 Original New Animal Drug Application.Novartis Animal Health US Inc.:2011. Available at:http:\/\/www.fda.gov\/downloads\/AnimalVeterinary\/Products\/ApprovedAnimalDrugProducts\/FOIADrugSummaries\/UCM287922.pdf. Accessed April 29 2012."},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2006.00110.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.11.018"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.152.24.739"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(86)90095-4"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2006.tb13119.x"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00371.x"},{"key":"e_1_2_5_31_2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.2460\/javma.1999.215.08.1123","article-title":"Acute toxoplasmosis following renal transplantation in three cats and a dog","volume":"215","author":"Bernsteen L","year":"1999","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.222.1097"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.948"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2008.00435.x"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1053\/jvet.2002.30540"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2008.00172.x"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3164.2012.01069.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3164.2012.01069.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T02:24:21Z","timestamp":1714098261000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3164.2012.01069.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,25]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1365-3164.2012.01069.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3164.2012.01069.x","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,25]]},"assertion":[{"value":"2012-06-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}