{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T20:47:00Z","timestamp":1771620420524,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,19]],"date-time":"2013-01-19T00:00:00Z","timestamp":1358553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p><jats:bold>Background\u00a0\u2013\u00a0<\/jats:bold>Pituitary pars intermedia dysfunction (PPID) in older equids is commonly recognized by a long hair coat that fails to shed.<\/jats:p><jats:p><jats:bold>Objective\u00a0\u2013\u00a0<\/jats:bold>The aim of this study was to compare hair follicle stages in PPID\u2010affected horses with excessively long hair coats with the stages of normal aged horses (controls) and to compare hair follicle stages in PPID\u2010affected horses after 6\u2003months of treatment with pergolide mesylate with those of control horses.<\/jats:p><jats:p><jats:bold>Animals\u00a0\u2013\u00a0<\/jats:bold>Eight PPID\u2010affected horses and four normal, age\u2010matched, control horses.<\/jats:p><jats:p><jats:bold>Methods\u00a0\u2013\u00a0<\/jats:bold>Skin biopsies were collected from the neck and rump of PPID\u2010affected and control horses. A diagnosis of PPID was established based on hair coat changes and supportive overnight dexamethasone suppression test results. Skin biopsies were repeated after 6\u2003months of treatment with pergolide. The number of hair follicles in anagen (A) or telogen (T) was counted for each skin biopsy using transverse sections.<\/jats:p><jats:p><jats:bold>Results\u00a0\u2013\u00a0<\/jats:bold>Pretreatment biopsies had a greater percentage of A follicles (neck 96%, rump 95%) and a lower percentage of T follicles (neck 4%, rump 5%) in PPID\u2010affected horses than in control horses (A, neck 15%, rump 25%; and T, neck 85%, rump 75%). After treatment with pergolide, all PPID\u2010affected horses had improved shedding, and the percentages of A follicles (neck 69%, rump 70%) and T follicles (neck 31%, rump 30%) were not different from untreated control horses (A, neck 68%, rump 82%; and T, neck 32%, rump 18%).<\/jats:p><jats:p><jats:bold>Conclusions\u00a0\u2013\u00a0<\/jats:bold>These findings document that excessive hair growth (hypertrichosis) in PPID\u2010affected horses is due to persistence of hair follicles in A. Furthermore, treatment with pergolide improved shedding and reduced the percentage of A follicles in PPID\u2010affected horses.<\/jats:p>","DOI":"10.1111\/j.1365-3164.2012.01080.x","type":"journal-article","created":{"date-parts":[[2013,1,19]],"date-time":"2013-01-19T14:29:52Z","timestamp":1358605792000},"page":"212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Comparison of hair follicle histology between horses with pituitary pars intermedia dysfunction and excessive hair growth and normal aged horses"],"prefix":"10.1111","volume":"24","author":[{"given":"Marie","family":"Inner\u00e5","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette D.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle R.","family":"Desjardins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"Steficek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Edmund J.","family":"Rosser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"II","given":"Harold C.","family":"Schott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0739(02)00018-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2010.12.007"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2010.00638.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2010.00142.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.1992.tb01594.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-070202823-6.50166-4"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0920-9.00010-X"},{"key":"e_1_2_6_9_2","first-page":"921","article-title":"Treatment of hypophyseal adenomas","volume":"16","author":"Beech J","year":"1994","journal-title":"Compend Cont Educ Pract Vet"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2002.tb02418.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.2746\/042516402776250333"},{"key":"e_1_2_6_12_2","first-page":"159","volume-title":"Advances in Veterinary Dermatology","author":"Schott HC","year":"2005"},{"key":"e_1_2_6_13_2","unstructured":"Freedom of Information Summary \u2013 NADA 141\u2010331 \u2013 Prascend tablets for the control of clinical signs associated with pituitary pars intermedia dysfunction (equine Cushing\u2019s disease) in horses. 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