{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:42:29Z","timestamp":1789868549938,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,8,2]],"date-time":"2012-08-02T00:00:00Z","timestamp":1343865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p><jats:bold>Background\u00a0\u2013\u2002<\/jats:bold> Coagulase\u2010negative <jats:italic>Staphylococcus lugdunensis<\/jats:italic> has recently been shown to cause invasive infections of people, which are similar in pathogenic effect to those caused by <jats:italic>Staphylococcus aureus<\/jats:italic>. Little is known about the pathogenicity of <jats:italic>S.\u00a0lugdunensis<\/jats:italic> in companion animals.<\/jats:p><jats:p><jats:bold>Objectives\u00a0\u2013\u2002<\/jats:bold> To compare potential risk factors for infection, body sites affected, and whether cases and controls had been treated with antimicrobial drugs based upon susceptibility test results.<\/jats:p><jats:p><jats:bold>Animals\u00a0\u2013\u2002<\/jats:bold> Thirty\u2010three cases of <jats:italic>S.\u00a0lugdunensis<\/jats:italic> infection (25 dogs, six cats and two small mammals) were identified between January 2003 and August 2011. Two <jats:italic>Staphylococcus pseudintermedius<\/jats:italic> controls, which were identified by the microbiology laboratory immediately before and after each <jats:italic>S.\u00a0lugdunensis<\/jats:italic> case, were host\u2010species matched to each case.<\/jats:p><jats:p><jats:bold>Methods\u00a0\u2013\u2002<\/jats:bold> A retrospective case\u2013control analysis.<\/jats:p><jats:p><jats:bold>Results\u00a0\u2013\u2002<\/jats:bold> During the period evaluated, the prevalence of <jats:italic>S.\u00a0lugdunensis<\/jats:italic> infection was 1.3\u2003cases per 10,000 hospital admissions for dogs and 0.95 cases per 10,000 admissions for cats (<jats:italic>P<\/jats:italic>\u2003=\u20030.453). In univariate analyses, <jats:italic>S.\u00a0pseudintermedius<\/jats:italic> isolation was significantly associated with skin infections (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001), while <jats:italic>S.\u00a0lugdunensis<\/jats:italic> isolation was associated with the respiratory tract (<jats:italic>P<\/jats:italic>\u2003=\u20030.03) and other deep tissues (<jats:italic>P<\/jats:italic>\u2003=\u20030.005). Cases were less likely than controls to have been treated based upon susceptibility test results (<jats:italic>P<\/jats:italic>\u2003=\u20030.02). A conditional logistic regression analysis showed isolation of <jats:italic>S.\u00a0lugdunensis<\/jats:italic> to be associated with recent (\u2264\u200330\u2003days) steroid administration (odds ratio, 17.72; 95% confidence interval, 2.35\u2013132.82; <jats:italic>P<\/jats:italic>\u2003=\u20030.005); and in\u2010patient status (odds ratio, 9.67; 95% confidence interval, 2.18\u201342.88; <jats:italic>P<\/jats:italic>\u2003=\u20030.003).<\/jats:p><jats:p><jats:bold>Conclusions\u00a0\u2013\u2002<\/jats:bold> These results suggest that <jats:italic>S.\u00a0lugdunensis<\/jats:italic> may cause invasive infections in companion animals, which should be treated with antimicrobials based upon susceptibility tests when 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