{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:30:20Z","timestamp":1779208220544,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,19]],"date-time":"2013-01-19T00:00:00Z","timestamp":1358553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p><jats:bold>Background\u2002\u2013\u2002<\/jats:bold> Dogs and humans with atopic dermatitis (AD) are predisposed to colonization and recurrent infection with <jats:italic>Staphylococcus<\/jats:italic> spp. Studies in humans suggest that staphylococcus\u2010specific immunoglobulin\u2003E (IgE) plays a key role in disease pathogenesis. Few such studies have been undertaken in dogs.<\/jats:p><jats:p><jats:bold>Hypothesis\/Objectives\u2002\u2013\u2002<\/jats:bold> The aim of this study was to compare levels of staphylococcus\u2010specific IgE and immunoglobulin\u2003G (IgG) in dogs with AD, nonatopic dogs with staphylococcal pyoderma, and nonatopic and noninfected control dogs.<\/jats:p><jats:p><jats:bold>Animals\u2002\u2013\u2002<\/jats:bold> Sera were collected from 108 dogs with AD, 39 nonatopic dogs with staphylococcal pyoderma secondary to different underlying conditions, 67 age\u2010matched nonatopic control dogs, and nine control dogs reared in minimal disease conditions.<\/jats:p><jats:p><jats:bold>Methods\u2002\u2013\u2002<\/jats:bold> Serum <jats:italic>Staphylococcus pseudintermedius<\/jats:italic>\u2010specific IgE and IgG antibodies were measured by enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:bold>Results\u2002\u2013\u2002<\/jats:bold> Dogs with AD had significantly higher levels of anti\u2010staphylococcal IgE than nonatopic dogs with staphylococcal pyoderma and the two groups of control dogs. Levels of anti\u2010staphylococcal IgG were significantly higher in atopic dogs and nonatopic dogs with pyoderma compared with nonatopic control dogs and control dogs reared in minimal disease conditions, but there was no significant difference in levels of anti\u2010staphylococcal IgG between dogs with AD and nonatopic dogs with pyoderma.<\/jats:p><jats:p><jats:bold>Conclusions and clinical importance\u2002\u2013\u2002<\/jats:bold> A significantly increased IgE response to <jats:italic>S.\u00a0pseudintermedius<\/jats:italic> antigens in atopic dogs suggests an immunopathogenic role for anti\u2010staphylococcal IgE. The finding of elevated IgE and IgG in atopic dogs is also important as a prelude to studies on antigenic specificity and possible correlations with disease phenotype.<\/jats:p>","DOI":"10.1111\/j.1365-3164.2012.01109.x","type":"journal-article","created":{"date-parts":[[2013,1,19]],"date-time":"2013-01-19T14:29:52Z","timestamp":1358605792000},"page":"19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Serum anti\u2010<i>Staphylococcus pseudintermedius<\/i> IgE and IgG antibodies in dogs with atopic dermatitis and nonatopic dogs"],"prefix":"10.1111","volume":"24","author":[{"given":"Jennifer","family":"Bexley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Nuttall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Hammerberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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