{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:05:14Z","timestamp":1758395114723},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,4,29]],"date-time":"2004-04-29T00:00:00Z","timestamp":1083196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> We have previously found that psoriatic patients have IgG autoantibodies that recognize lesions but not autologous normal skin. The reactivity of the autoantibodies can be adsorbed with streptococcal antigens.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> IgG antibodies were determined by immunoblot and ELISA to streptococcal antigens and by ELISA to the recombinants HSP60Sp, HSP70Sp, HSP60Ec and HSP60Hu, in plaque (PP) and guttate (GP) psoriasis patients, in healthy subjects (HC) and in individuals with streptococcal throat infections and high ASO titers, but without history of dermatological disease (ISp).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> We found by immunoblot that the IgG response to 71\u2010, 60\u2010, and 14\u2010kDa protein fractions of <jats:italic>Streptococcus pyogenes<\/jats:italic> is important in psoriasis. We also found by ELISA that the response to the rHSP60Sp in PP was higher than in all the other three groups studied (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) with an odds ratio of 11.11 (CI95% of 4.33\u201328.49). The PP infected with <jats:italic>S. pyogenes<\/jats:italic> had higher titers of the antirHSP60Sp, high ASO, and high PASI. The PP patients did not significantly recognize the HSP60Ec or the HSP60Hu. The GP patients had a higher response to the rHSP60Sp than the healthy controls or ISp patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) but showed no association with the disease. The response of the ISp patients to the HSP60Sp was similar to the healthy controls. The response to the rHSP70Sp was similar in the PP patients and the healthy controls.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Results suggest that a high response to the HSP60Sp could be associated with the chronic form of psoriasis.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.01884.x","type":"journal-article","created":{"date-parts":[[2004,4,29]],"date-time":"2004-04-29T12:34:04Z","timestamp":1083242044000},"page":"341-347","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["IgG class antibodies from psoriasis patients recognize the 60\u2010KDa heat\u2010shock protein of <i>Streptococcus pyogenes<\/i>"],"prefix":"10.1111","volume":"43","author":[{"given":"Mario E.","family":"Cancino\u2010D\u00edaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Ruiz\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Ram\u00edrez\u2010Res\u00e9ndiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Lilia","family":"Dom\u00ednguez\u2010L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna C.","family":"Paredes\u2010Cabrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladys","family":"Le\u00f3n\u2010Dorantes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Blancas\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Jim\u00e9nez\u2010Zamudio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethel","family":"Garc\u00eda\u2010Latorre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,4,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12608210"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1977.tb14130.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb06036.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00224.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1997.d01-438.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"276","DOI":"10.2340\/0001555574279282","article-title":"Decreased T cell reactivity to trypsinized group A, type M22 streptococci in psoriasis","volume":"74","author":"Baker BS","year":"1994","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050426"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118263"},{"key":"e_1_2_6_10_2","first-page":"399","article-title":"Antibodies to streptococcal cell wall in psoriatic arthritis and cutaneous psoriasis","volume":"15","author":"Rantakokko K","year":"1997","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1996.tb02687.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2340\/0001555577175180","article-title":"Detection of streptococcal class I M protein in psoriasis by confocal immunofluorescent microscopy","volume":"77","author":"Talanin NY","year":"1997","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1996.tb01087.x"},{"key":"e_1_2_6_14_2","first-page":"143","article-title":"Recognition of Streptococcus pyogenes and skin autoantigens in guttate psoriasis","volume":"29","author":"Villeda\u2010Gabriel G","year":"1998","journal-title":"Arch Med Res"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00512.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.002153"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","unstructured":"P\u00e9rez LorenzoR Zambrano\u2010ZaragozaJF Moo\u2010CastilloK et al.IgG class antibodies to heat shock\u2010induced streptococcal antigens in psoriatic patients.Int J Dermatol2003;42:110\u2013115.","DOI":"10.1046\/j.1365-4362.2003.01736.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.9.4350"},{"key":"e_1_2_6_20_2","first-page":"1756","article-title":"Antibody response to Klebsiella pneumoniae 60 kDa protein in familial and sporadic ankylosing spondylitis: Role of HLA\u201027 and characterization as a GroEL\u2010like protein","volume":"25","author":"Cancino\u2010D\u00edaz M","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1992.01680110049004"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00622.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb15144.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1975.tb03104.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12524838"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90291-0"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(95)80132-4"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12354979"},{"key":"e_1_2_6_29_2","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.4049\/jimmunol.162.6.3212","article-title":"Human 60\u00a0KDa heat.\u2010shock protein: a danger signal to the innate immune system","volume":"162","author":"Chen W","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_6_30_2","doi-asserted-by":"crossref","first-page":"558","DOI":"10.4049\/jimmunol.164.2.558","article-title":"Heat shock protein 60 is a putative endogenous ligand of the toll\u2010like\u20104 complex","volume":"164","author":"Ohashi K","year":"2000","journal-title":"J Immunol"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.1.13"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2004.01884.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2004.01884.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T21:57:07Z","timestamp":1696888627000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2004.01884.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,29]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1111\/j.1365-4632.2004.01884.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2004.01884.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,29]]},"assertion":[{"value":"2004-04-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}