{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:18:15Z","timestamp":1770477495232,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,8,3]],"date-time":"2004-08-03T00:00:00Z","timestamp":1091491200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Calcipotriol and corticosteroids are commonly used treatments for psoriasis vulgaris, each with different mechanisms of action. The two agents have shown combined action, but current formulations do not permit simultaneous application. Daivobet\u00ae (LEO Pharma, Denmark) ointment contains calcipotriol and the corticosteroid, betamethasone dipropionate. Such a formulation may provide convenience and enhanced activity compared with separate applications, but it is essential that the biological activity and bioavailability of either active agent is not adversely affected by the other component.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> his study was designed to determine whether the bioavailability of the corticosteroid component of Daivobet\u00ae was equivalent to that in a corticosteroid\u2010only formulation (Diprosone\u00ae, Schering\u2010Plough Laboratories, France).<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> A vasoconstrictor assay measuring skin blanching was used to determine bioequivalence.<\/jats:p><jats:p><jats:bold>Result\u2002<\/jats:bold> Skin blanching measured either by objective chromametric measurement or visual assessment showed Daivobet\u00ae to be equivalent to Diprosone\u00ae.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The data indicate that the steroid component of Daivobet\u00ae is not unfavorably affected by the calcipotriol.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.01922.x","type":"journal-article","created":{"date-parts":[[2004,8,4]],"date-time":"2004-08-04T09:11:53Z","timestamp":1091610713000},"page":"611-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Bioavailability of betamethasone dipropionate when combined with calcipotriol"],"prefix":"10.1111","volume":"43","author":[{"given":"Jette","family":"Traulsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,3]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92157-W"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70299-U"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7240.963"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70103-M"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70237-3"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000029913"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02553.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70320-7"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000211446"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.18511944.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90349-7"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02070.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02461.x"},{"key":"e_1_2_5_15_2","first-page":"746","article-title":"Psoriasis: New treatment modality with calcipotriol and betamethasone diproprionate","volume":"13","author":"Ortonne JP","year":"1994","journal-title":"Nouw Dermatol"},{"key":"e_1_2_5_16_2","unstructured":"FDA Guidance.Topical dermatological corticosteroids: in vivo bioequivalence. Division of bioequivalence Office of generic drugs Rockville MD:Food and Drug Administration 1995."},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01059558"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04967.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","unstructured":"PappKA GuentherL BoydenB et al.Early onset of action and efficacy of a combination of calcipotriene and betamethasone dipropionate in the treatment of psoriasis.J Am Acad Dermatol2003;48:48\u201354.","DOI":"10.1067\/mjd.2003.130"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/00015550252948194"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000066440"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2004.01922.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2004.01922.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T21:30:18Z","timestamp":1696887018000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2004.01922.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["10.1111\/j.1365-4632.2004.01922.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2004.01922.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8]]},"assertion":[{"value":"2004-08-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}