{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T09:24:50Z","timestamp":1750843490640},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,3,22]],"date-time":"2004-03-22T00:00:00Z","timestamp":1079913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p>A 27\u2010year\u2010old man presented to our clinic with an asymptomatic papular eruption all over his body. The eruption first began after hepatitis B vaccination (Engerix B) and increased with the second vaccination which was given 1\u00a0month after the first.<\/jats:p><jats:p>His medical history and systemic examination were normal. Physical examination revealed numerous, flesh\u2010colored or pink, 1\u20132\u00a0mm papules, with a flat, shiny surface, predominantly on the trunk and arms, and grouped in some areas. The face, nails, and oral mucosa were spared. Laboratory investigation revealed normal values of the routine hematologic and biochemical tests. Antistreptolysin O (ASO), C\u2010reactive protein (CRP), venereal disease research laboratory (VDRL) test, anti\u2010human immunodeficiency virus (anti\u2010HIV), chest X\u2010ray, and ultrasonography were normal. Anti\u2010hepatitis A virus immunoglobulin M (anti\u2010HAV IgM), anti\u2010hepatitis B core total (anti\u2010HBc total), and anti\u2010hepatitis C virus (anti\u2010HCV) were negative. Anti\u2010hepatitis A virus immunoglobulin G (anti\u2010HAV IgG) was positive; 10\u00a0mm erythema and induration were detected in the purified protein derivative (PPD) test.<\/jats:p><jats:p>During the following period, spontaneous resolution of the lesions was observed. When the hepatitis B vaccine was given to the patient again after several months, however, the same types of lesion re\u2010occurred and spread rapidly all over his body. Again, physical examination revealed numerous, flesh\u2010colored or pink, 1\u20132\u00a0mm papules, with a flat, shiny surface, on the trunk, arms, and penis (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f1\">Fig.\u00a01<\/jats:ext-link>). Laboratory investigations revealed normal hematologic and biochemical values. Anti\u2010hepatitis B surface antigen (anti\u2010HBsAg) was &gt;\u00a0150\u00a0IU\/mL. Histopathologic examination of skin biopsy material taken from the regio antebrachii revealed, in the dermis, a granuloma formation of lymphocytes, histiocytes, and plasma cells which was surrounded by rete ridges and covered with focal parakeratotic epidermis (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f2\">Fig.\u00a02<\/jats:ext-link>).<\/jats:p><jats:p><jats:fig><jats:caption><jats:p>Numerous, flesh\u2010colored to pink papules with a flat, shiny surface<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:00119059:media:IJD1933:IJD_1933_f1\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p><jats:fig><jats:caption><jats:p>Granuloma formation with histiocytes, lymphocytes, and plasma cells in the dermis (hematoxylin and eosin, \u00d7\u00a040)<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:00119059:media:IJD1933:IJD_1933_f2\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p>During the following period, spontaneous resolution of the lesions began and, with the addition of topical corticosteroid, the improvement increased. During the 1\u2010year follow\u2010up period after complete resolution of the lesions, no further exacerbation was detected.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.01933.x","type":"journal-article","created":{"date-parts":[[2004,11,26]],"date-time":"2004-11-26T10:05:43Z","timestamp":1101463543000},"page":"956-958","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lichen nitidus after hepatitis B vaccine"],"prefix":"10.1111","volume":"43","author":[{"given":"Emel","family":"Fetil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eebnem","family":"\u00d6zkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nalan","family":"G\u00fcrler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emel","family":"Polat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eenel","family":"Yurtsever","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahrinur","family":"Dorak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"K\u00fcpelio\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,9]]},"reference":[{"key":"e_1_2_2_2_2","unstructured":"DaoudMS PittelkowMR.Lichen nitidus. 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