{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:59:39Z","timestamp":1792627179327,"version":"4.5.0"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,4,6]],"date-time":"2004-04-06T00:00:00Z","timestamp":1081209600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Cutaneous leishmaniasis (CL) is a parasitic disease caused by <jats:italic>Leishmania<\/jats:italic> species. There is a need for more effective and less time\u2010consuming therapeutic methods for this condition.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To evaluate the efficacy of combined cryotherapy and intralesional meglumine antimoniate (MA) (Glucantime\u00ae, Specia, Paris, France) for the treatment of CL.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Patients were divided into three groups: Group 1, 100 patients with 149 lesions were treated with cryotherapy plus intralesional MA; Group 2, 200 patients with 230 lesions were treated with cryotherapy; Group 3, 100 patients with 160 lesions were treated with intralesional MA. These groups were followed for 6\u00a0months after the end of treatment.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The results showed complete cure in 90.9% of cases in Group 1, 57.15% of cases in Group 2, and 55.63% of cases in Group 3. The difference between Group 1 and the other groups was statistically significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Combined cryotherapy and intralesional MA is more effective than either cryotherapy or intralesional MA alone for the treatment of CL.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02002.x","type":"journal-article","created":{"date-parts":[[2004,4,6]],"date-time":"2004-04-06T16:15:02Z","timestamp":1081268102000},"page":"281-283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Comparative study of the efficacy of combined cryotherapy and intralesional meglumine antimoniate (Glucantime\u00ae) vs. cryotherapy and intralesional meglumine antimoniate (Glucantime\u00ae) alone for the treatment of cutaneous leishmaniasis"],"prefix":"10.1111","volume":"43","author":[{"given":"A.","family":"Asilian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sadeghinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Faghihi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Momeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,4,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(96)00058-2"},{"key":"e_1_2_6_3_2","volume-title":"Control of Leishmanisis. 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