{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:42:14Z","timestamp":1762504934638},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,5,28]],"date-time":"2004-05-28T00:00:00Z","timestamp":1085702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Autoantibodies in linear immunoglobulin A (IgA) disease (LAD) are reported to be of IgA class and directed against a 97\u2013120\u00a0kDa epidermal antigen.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We report a 39\u2010year\u2010old woman with clinical features of LAD and with circulating IgA and IgG autoantibodies to the 180\u00a0kDa bullous pemphigoid antigen (BP180).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Histopathology of lesional skin revealed a subepidermal blister with mixed inflammatory cell infiltrate. Direct immunofluorescence of perilesional skin showed linear deposits of IgA along the dermal\u2013epidermal junction. The antigen specificity of the patient's circulating antibodies was determined by Western blotting and enzyme\u2010linked immunoabsorbent assay (ELISA) using various antigen sources, including cultured human keratinocytes, dermal protein lysates, and purified laminin\u20105, as well as proteins corresponding to BP180, the 230\u00a0kDa bullous pemphigoid antigen (BP230), laminin\u20105 subunits, and collagen IV \u03b11\u2013\u03b16 chains. IgA and IgG antibodies in the patient's serum were directed against BP180, and no IgA or IgG reactivity was found against the other skin antigens.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> These data provide evidence for the presence of a subtype of LAD with dual IgA and IgG autoimmune response to BP180.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02016.x","type":"journal-article","created":{"date-parts":[[2004,5,28]],"date-time":"2004-05-28T14:46:27Z","timestamp":1085755587000},"page":"443-446","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Linear IgA dermatosis with IgA and IgG autoantibodies to the 180\u00a0kDa bullous pemphigoid antigen (BP180): evidence for a distinct subtype"],"prefix":"10.1111","volume":"43","author":[{"given":"Brandie J.","family":"Metz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun 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