{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T05:50:09Z","timestamp":1725256209949},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,4,16]],"date-time":"2004-04-16T00:00:00Z","timestamp":1082073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Beh\u00e7et's disease (BD) is a multisystemic disease of unknown etiology characterized by chronic relapsing oral\u2013genital ulcers and uveitis. Some abnormalities in lipoprotein metabolism have been described in patients with BD.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In this study, apolipoprotein E (apo E) polymorphism and lipoprotein cholesterol concentrations in 30 patients with BD were compared with those of 27 control subjects.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Both patients and controls were found to be normolipidemic. Patients with BD had significantly higher concentrations of high\u2010density lipoprotein (HDL) cholesterol than those of controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05); however, there was no difference in serum triglyceride, low\u2010density lipoprotein (LDL) and very low\u2010density lipoprotein (VLDL) cholesterol concentrations. The distribution of apo E genotypes and alleles was the same in both groups. There were slight differences in allele frequency between the groups, but this was not statistically significant.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The high HDL cholesterol levels observed in our patients were not related to abnormalities in apo E alleles.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02020.x","type":"journal-article","created":{"date-parts":[[2004,11,26]],"date-time":"2004-11-26T10:05:43Z","timestamp":1101463543000},"page":"900-903","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Apolipoprotein E polymorphism and lipoprotein compositions in patients with Beh\u00e7et's 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