{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:12:49Z","timestamp":1759335169567},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,9,7]],"date-time":"2004-09-07T00:00:00Z","timestamp":1094515200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Alpha\u20101\u2010antitrypsin is the principal serum protease inhibitor. In addition to the well\u2010recognized association with early\u2010onset emphysema and cirrhosis, alpha\u20101\u2010antitrypsin deficiency may be associated with panniculitis. The treatment of this type of panniculitis presents a significant challenge. Previous attempts using immunosuppressive, anti\u2010inflammatory, and cytotoxic drugs have shown variable results.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To report a case of alpha\u20101\u2010antitrypsin deficiency\u2010associated panniculitis treated with plasma exchange therapy.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A 23\u2010year\u2010old patient developed painful red nodules on her thighs and buttocks with spontaneous ulceration and discharge of oily fluid. A skin biopsy specimen showed septal and lobular panniculitis. The serum alpha\u20101\u2010antitrypsin level was 22\u00a0mg\/dL. She was treated with plasma exchange therapy.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Treatment of this patient with plasma exchange therapy led to the control of the cutaneous lesions.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Plasma exchange therapy represents an alternative treatment which restores serum and tissue alpha\u20101\u2010antitrypsin levels. This method is proposed because of its clinical benefits and greater availability.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02054.x","type":"journal-article","created":{"date-parts":[[2004,9,7]],"date-time":"2004-09-07T13:36:09Z","timestamp":1094564169000},"page":"693-697","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Alpha\u20101\u2010antitrypsin deficiency associated with panniculitis treated with plasma exchange therapy"],"prefix":"10.1111","volume":"43","author":[{"given":"Priscila","family":"De Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libania","family":"Paz\u2010Melgar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Denise F.","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello Menta S.","family":"Nico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evandro A.","family":"Rivitti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Alfredo","family":"Mendrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson H.","family":"Tatsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,7]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90436-0"},{"key":"e_1_2_4_3_2","first-page":"877","article-title":"Syndrome de Weber\u2013Christian associ\u00e9\u00e0 un d\u00e9ficit en alpha1\u2010antitrypsine. 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