{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:56:13Z","timestamp":1787014573297,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,3,16]],"date-time":"2004-03-16T00:00:00Z","timestamp":1079395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    Isotretinoin is widely used in the treatment of severe, recalcitrant, nodular acne. Mucocutaneous side\u2010effects are seen in the great majority of patients and some of them have elevations in their serum lipid and liver enzyme profiles. Recently, it has been shown that addition of vitamin E decreased the toxicity of high\u2010dose retinoids.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective\u2002<\/jats:bold>\n                    The purpose of this investigator\u2010blinded, randomized study was to assess whether vitamin E would reduce the side\u2010effects of isotretinoin in the treatment of acne vulgaris.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods\u2002<\/jats:bold>\n                    Eighty two patients were randomly assigned to one of two treatment groups with isotretinoin (1\u00a0mg\/kg\/day) alone or combined with vitamin E (800\u00a0IU\/day). The treatment duration was 16\u00a0weeks. Mucocutaneous side\u2010effects such as facial erythema, facial dryness, cheilitis and serum lipid and liver enzyme profiles were assessed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    There was no difference in the incidence and severity of side\u2010effects related to isotretinoin between the two treatment groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    Eight hundred IU\/day vitamin E did not improve the side\u2010effects of 1\u00a0mg\/kg\/day of isotretinoin in the treatment of acne vulgaris.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02072.x","type":"journal-article","created":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T09:54:59Z","timestamp":1110275699000},"page":"248-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Vitamin E does not reduce the side\u2010effects of isotretinoin in the treatment of acne vulgaris"],"prefix":"10.1111","volume":"44","author":[{"given":"Sadiye","family":"Kus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"G\u00fcn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Demir\u00e7ay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haydar","family":"Sur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,3,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80252-6"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08524.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113717"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80256-3"},{"key":"e_1_2_6_6_2","first-page":"1999","article-title":"Effect of 13\u2010cis\u2010retinoic acid and alpha\u2010interferon on transforming growth factor beta1 in patients with rising prostate\u2010specific antigen","volume":"3","author":"DiPaola RS","year":"1997","journal-title":"Clin Cancer Res"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1017\/S0022215100135169","article-title":"Treatment of unresectable recurrent head and neck carcinoma with 13\u2010cis\u2010retinoic acid and interferon\u2010alpha. 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