{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:15:00Z","timestamp":1790540100407,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,6,29]],"date-time":"2004-06-29T00:00:00Z","timestamp":1088467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Recent studies have suggested that there might be an etiologic role for <jats:italic>Helicobacter pylori<\/jats:italic> (HP) in rosacea. HP is a Gram\u2010negative bacterium that colonizes the gastric mucosa, increases the generation of reactive oxygen species (ROS), and decreases plasma antioxidants such as ascorbic acid.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To investigate plasma ROS activities and antioxidant status, and their relationship with HP infection, in rosacea patients.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Twenty\u2010nine rosacea patients and 20 age\u2010 and sex\u2010matched healthy controls were examined for specific immunoglobulin G (IgG) and IgM against HP, plasma malondialdehyde (MDA), and antioxidant potential (AOP) levels.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Compared with controls, the seropositivity of HP for IgM was significantly higher (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and the seropositivity of HP for IgG was significantly lower (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001) in patients with rosacea. Plasma MDA levels were higher (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001) and AOP levels were lower (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.019) in patients than in controls, regardless of the severity of the disease. Plasma MDA and AOP levels were not affected by the seropositivity of HP for IgM and\/or IgG in either group.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Our results suggest that rosacea is an oxidative stress condition, as reflected by the increased ROS activity and decreased AOP, regardless of HP infection.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02137.x","type":"journal-article","created":{"date-parts":[[2004,7,2]],"date-time":"2004-07-02T06:11:27Z","timestamp":1088748687000},"page":"494-497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Plasma reactive oxygen species activity and antioxidant potential levels in rosacea patients: correlation with seropositivity to <i>Helicobacter pylori<\/i>"],"prefix":"10.1111","volume":"43","author":[{"given":"Kiymet","family":"Baz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Y. 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