{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T21:23:12Z","timestamp":1772659392843,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,7,22]],"date-time":"2004-07-22T00:00:00Z","timestamp":1090454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Lichen planus (LP) is classified as a papulosquamous disease. It has been associated with liver disease, particularly hepatitis C virus (HCV) infection, in several studies. Most of these reports, especially the larger series, were conducted in Europe and Japan.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> We conducted a case\u2013control study in Kerman, Iran to explore the association between LP and HCV.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> The study included 66 patients with LP (as cases; mean age\u00a0=\u00a039.7\u00a0\u00b1\u00a015.8\u00a0years; 31 female, 35 male) and 140 volunteer blood donors (as controls; mean age\u00a0=\u00a029.5\u00a0\u00b1\u00a08.4\u00a0years; 43 females, 97 males). An enzyme\u2010linked immunosorbent assay (ELISA) was used to determine the presence of anti\u2010HCV antibodies in all subjects in both groups. To confirm positive diagnoses, a second generation recombinant immunoblot assay (RIBA II) test was performed.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Lichen planus lesions were most frequently located on the trunk and extremities, and the most common clinical type was generalized LP (48.5%). One of the patients with LP (1.5%) and three of the controls (2.1%) were HCV\u2010Ab positive. No significant difference was observed in HCV\u2010Ab positive between the two groups (OR\u00a0=\u00a00.7; 95% CI\u00a0=\u00a00.1\u20136.9).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The findings indicate that an investigation for HCV infection should not necessarily be performed in all patients with LP. It is recommended that further studies should focus on larger groups in other regions of Iran to determine whether testing for HCV infection is necessary in patients with LP.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02176.x","type":"journal-article","created":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T08:23:10Z","timestamp":1125044590000},"page":"746-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The relationship between lichen planus and hepatitis C in dermatology outpatients in Kerman, Iran"],"prefix":"10.1111","volume":"44","author":[{"given":"Zahra","family":"Rahnama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iraj","family":"Esfandiarpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saideh","family":"Farajzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,22]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1899","volume-title":"Rook\/Wilkinson\/Ebling Text Book of Dermatology","author":"Black MM","year":"1998"},{"key":"e_1_2_6_3_2","first-page":"561","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Dauod MS","year":"1999"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.111624"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.4065\/70.6.559"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1998.tb00922.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155598443051"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1001\/archderm.1995.01690220091017","article-title":"Hepatitis C virus in dermatology","volume":"131","author":"Pawlotsky JM","year":"1995","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.109311"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(98)80101-X"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290603.x"},{"key":"e_1_2_6_12_2","first-page":"242","article-title":"Survey of prevalence of HCV in volunteer blood donors referred to blood transfusion organization in Ormieh city","volume":"9","author":"Sadeghi A","year":"1999","journal-title":"Ormieh Med Sci J"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2000.00903.x"},{"key":"e_1_2_6_14_2","first-page":"14","volume-title":"Adequacy of Sample Size in Health Studies","author":"Lemshow S","year":"1990"},{"key":"e_1_2_6_15_2","first-page":"7","article-title":"Survey of prevalence of HBSAg positive lichen planus out patients in Khatam al anbia hospital in Zahedan 1998\u201399","volume":"2","author":"Banihashem M","year":"2000","journal-title":"Iranian J Dermatol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2000.tb02232.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2000.00903.x"},{"key":"e_1_2_6_18_2","first-page":"77","article-title":"Previous tuberculosis, hepatitis C virus and lichen planus. 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