{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:09:46Z","timestamp":1791328186000,"version":"4.3.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,7,22]],"date-time":"2004-07-22T00:00:00Z","timestamp":1090454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Immune dysregulation has been shown to be one of the major aspects of the yet unknown pathogenesis of Beh\u00e7et's disease. Interleukin\u20108 (IL\u20108), a major chemokine with pivotal effects concerning leukocytes and endothelial cells, has been found to be elevated in patients with Beh\u00e7et's disease.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To evaluate the significance of elevated levels of IL\u20108 with respect to the activity of Beh\u00e7et's disease.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Sixty\u2010seven consecutive patients with Beh\u00e7et's disease (37 males, 30 females; 32.5\u00a0\u00b1\u00a09.3\u00a0years) were enrolled in our study. The number of active clinical manifestations at the time of serum sampling was recorded. The degree of association between disease activity and IL\u20108, C\u2010reactive protein, and erythrocyte sedimentation rate was assessed.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Serum levels of IL\u20108 increased as the number of clinically involved organs increased (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). C\u2010reactive protein and the erythrocyte sedimentation rate showed no correlation with disease activity.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Our study confirms that the IL\u20108 level is a more sensitive marker of disease activity than the erythrocyte sedimentation rate and C\u2010reactive protein. It may be assumed that IL\u20108 plays an important role in the pathophysiology of Beh\u00e7et's disease.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02184.x","type":"journal-article","created":{"date-parts":[[2005,8,3]],"date-time":"2005-08-03T16:10:53Z","timestamp":1123085453000},"page":"657-660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Serum interleukin\u20108 as a serologic marker of activity in Beh\u00e7et's disease"],"prefix":"10.1111","volume":"44","author":[{"given":"G\u00fcne\u015f","family":"G\u00fcr\u2010Toy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurdan","family":"Lenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basak","family":"Yalcin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabahat","family":"Aksaray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuran","family":"Alli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,20]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1152","article-title":"Uber rezidivirende Aphtose, durch ein Virus verursachte Geschwure am Mund, am Auge und an den Genitalien","volume":"105","author":"Beh\u00e7et H","year":"1937","journal-title":"Dermatol Wochenschr"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02912462"},{"key":"e_1_2_6_4_2","first-page":"249","article-title":"IL\u20108 producing cells in patients with Beh\u00e7et's disease","volume":"18","author":"Mantas C","year":"2000","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_5_2","first-page":"1544","article-title":"Overproduction of monocyte derived tumor necrosis factor \u03b1, IL\u20106, IL\u20108 and increased neutrophil superoxide generation in Beh\u00e7et's disease. 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Relation of serum C\u2010reactive protein and erythrocyte sedimentation rates to disease activity","volume":"25","author":"M\u00fct\u00fco\u011flu A\u00dc","year":"1986","journal-title":"Int J Dermatol"},{"key":"e_1_2_6_18_2","first-page":"128","article-title":"Systemic levels of the T cell regulatory cytokines IL\u201010 and IL\u201012 in Beh\u00e7et's disease; soluble TNFR\u201075 as a biological marker of disease activity","volume":"24","author":"Turan B","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/23.4.283"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2004.02184.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2004.02184.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T08:35:29Z","timestamp":1696926929000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2004.02184.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,20]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1111\/j.1365-4632.2004.02184.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2004.02184.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,20]]},"assertion":[{"value":"2005-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}