{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:47:46Z","timestamp":1780447666928,"version":"3.54.1"},"reference-count":7,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,6,8]],"date-time":"2004-06-08T00:00:00Z","timestamp":1086652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Epidermolysis bullosa acquisita (EBA) is a rare antibody\u2010mediated autoimmune blistering disease of adults. Likewise, acquired factor VIII deficiency is a rare antibody\u2010mediated disease of adulthood. Both diseases can be exceedingly difficult to treat and refractory to immunomodulatory therapies.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Herein, we report a challenging case of EBA and acquired factor VIII deficiency in the same patient.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Cyclosporine 4\u00a0mg\/kg\/day rapidly controlled both disease processes after the patient failed to respond to prednisone, colchicine, and pulse cyclophosphamide. The EBA relapsed when the cyclosporine was decreased to 2\u00a0mg\/kg\/day and the patient wore snuggly fitting new shoes, but it cleared quickly when the dose was increased. Cyclosporine has since been decreased gradually to 1.5\u00a0mg\/kg\/day without relapse of either condition or detectable side\u2010effects.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Cyclosporine should be considered when EBA and\/or acquired factor VIII deficiency fail to respond to conservative therapy. Both conditions usually respond rapidly to cyclosporine 4\u20136\u00a0mg\/kg\/day.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02245.x","type":"journal-article","created":{"date-parts":[[2005,8,3]],"date-time":"2005-08-03T16:10:53Z","timestamp":1123085453000},"page":"692-694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Cyclosporine controls epidermolysis bullosa acquisita co\u2010occurring with acquired factor VIII deficiency"],"prefix":"10.1111","volume":"44","author":[{"suffix":"Jr","given":"John C.","family":"Maize","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack B.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8652(199603)51:3<250::AID-AJH2830510302>3.0.CO;2-L"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00289-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70254-6"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.4065\/71.12.1182"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2340\/0001555573229230","article-title":"Pemphigus vulgaris associated with acquired hemophilia A due to factor VIII inhibitor","volume":"73","author":"Ishikawa O","year":"1993","journal-title":"Acta Dermatol Venereol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.116791"},{"key":"e_1_2_6_8_2","first-page":"895","article-title":"Cyclosporine treatment of acquired hemophilia due to factor VIII antibodies","volume":"85","author":"Petrovic M","year":"2000","journal-title":"Haematol"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2004.02245.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2004.02245.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T08:37:25Z","timestamp":1696927045000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2004.02245.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,20]]},"references-count":7,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1111\/j.1365-4632.2004.02245.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2004.02245.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,20]]},"assertion":[{"value":"2005-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}