{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:42:55Z","timestamp":1782963775507,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,4,29]],"date-time":"2004-04-29T00:00:00Z","timestamp":1083196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Systemic antibiotics such as tetracycline are well accepted as effective in treating the inflammatory papular\/pustular phase of rosacea but may be associated with systemic side\u2010effects. Few controlled data on the use of topical antibiotics in rosacea are available.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> We evaluated the efficacy and tolerability of a fixed combination of 5% benzoyl peroxide and 1% clindamycin in a topical gel for the treatment of rosacea.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> This was a 12\u2010week, double\u2010blind, vehicle\u2010controlled, randomized, prospective, parallel\u2010group study in 53 patients with moderate to severe rosacea.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The mean percentage reduction in papules and pustules from baseline to the end of treatment was 71.3% in the benzoyl peroxide\/clindamycin group (<jats:italic>n<\/jats:italic>\u00a0=\u00a026) and 19.3% in the vehicle group (<jats:italic>n<\/jats:italic>\u00a0=\u00a026; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0056). A significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0141) difference in favor of benzoyl peroxide\/clindamycin was evident by the third week of treatment. Severity scores for erythema, papules\/pustules, and flushing\/blushing decreased more with benzoyl peroxide\/clindamycin than with vehicle. Overall rosacea severity, Physician Global Assessment, and Patient's Global Assessment at the end of treatment were all significantly improved with benzoyl peroxide\/clindamycin compared with vehicle (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0101, 0.0026, and 0.0002, respectively). Application site reactions were reported in four patients (14.8%) in the benzoyl peroxide\/clindamycin group.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> A once\u2010daily topical application of a combination of 5% benzoyl peroxide and 1% clindamycin is effective and well tolerated in patients with moderate to severe rosacea.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02283.x","type":"journal-article","created":{"date-parts":[[2004,4,29]],"date-time":"2004-04-29T12:34:04Z","timestamp":1083242044000},"page":"381-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Double\u2010blind, randomized, vehicle\u2010controlled clinical trial of once\u2010daily benzoyl peroxide\/clindamycin topical gel in the treatment of patients with moderate to severe rosacea"],"prefix":"10.1111","volume":"43","author":[{"given":"Debra","family":"Breneman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Savin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"VandePol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Vamvakias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Leyden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,4,29]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"214","article-title":"Diagnosis and treatment of rosacea","volume":"15","author":"Cohen AF","year":"2002","journal-title":"J Am Board Fam Pract"},{"key":"e_1_2_5_3_2","first-page":"435","article-title":"Rosacea: a common, yet commonly overlooked, condition","volume":"66","author":"Blount BW","year":"2002","journal-title":"Am Fam Physician"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200203070-00005"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"e_1_2_5_6_2","first-page":"149","article-title":"Treatment of rosacea with doxycycline monohydrate","volume":"66","author":"Bikowski JB","year":"2000","journal-title":"Cutis"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1983.tb04003.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00301.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1993.tb00974.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.67.8.587"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1968.tb12288.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1969.01610300033005"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1001\/archderm.1981.01650080036024","article-title":"Topical clindamycin therapy for acne vulgaris. 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