{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:25:53Z","timestamp":1771673153689,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,8,24]],"date-time":"2004-08-24T00:00:00Z","timestamp":1093305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Hyperhidrosis (excessive, uncontrollable sweating) can be embarrassing and disabling, significantly impacting social and professional performance and quality of life. Treatments aim to reduce sweating, but few are effective, often carrying the risk of significant side\u2010effects. The aims of this study were to evaluate the efficacy and safety of botulinum toxin type A (BTX\u2010A) for plantar hyperhidrosis and to investigate the role of the Dermojet as a potential injection technique.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Ten adult patients (five men, five women), aged 19\u201351\u00a0years, with severe, previously unresponsive, plantar hyperhidrosis, were recruited to this single\u2010center, open\u2010label, noncomparative study. The hyperhidrotic area of each foot was injected over 15\u201320 sites without analgesia with 50\u00a0U BTX\u2010A\u00a0+\u00a05\u00a0mL sterile saline using a Dermojet. Patients were followed up for 8\u00a0months with monthly sweat reduction assessments using Minor's iodine\u2013starch test. Patients provided a treatment self\u2010assessment after completion of follow\u2010up.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Within 7\u00a0days post\u2010treatment, eight patients reported significantly decreased sweating, and seven patients were symptom free for up to 5\u00a0months. Patient self\u2010assessment showed that seven of the 10 patients were satisfied with their treatment. One minor adverse event was reported comprising a temporary localized hematoma (one patient).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Intracutaneous BTX\u2010A injection using the Dermojet offers a simple, safe, and effective alternative for treatment of plantar hyperhidrosis.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02304.x","type":"journal-article","created":{"date-parts":[[2004,11,26]],"date-time":"2004-11-26T10:05:43Z","timestamp":1101463543000},"page":"969-971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Treatment of plantar hyperhidrosis with botulinum toxin type A"],"prefix":"10.1111","volume":"43","author":[{"given":"Javid","family":"Vadoud\u2010Seyedi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.1999.tb00027.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02291235"},{"issue":"2","key":"e_1_2_6_4_2","first-page":"S75","article-title":"The treatment of focal hyperhidrosis with botulinum toxin","volume":"4","author":"Naver H","year":"1997","journal-title":"Eur J Neurol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.2576k.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000018469"},{"key":"e_1_2_6_7_2","first-page":"863","article-title":"Treatment of hyperhidrosis","volume":"16","author":"Stolman LP","year":"1998","journal-title":"Curr Ther"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb03521.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800770931"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000051780"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1998.tb04257.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00350.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.d01-1233.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.3.301"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1998.tb04104.x"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2004.02304.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2004.02304.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T20:21:45Z","timestamp":1697314905000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2004.02304.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,24]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1111\/j.1365-4632.2004.02304.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2004.02304.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8,24]]},"assertion":[{"value":"2004-08-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}