{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:25:34Z","timestamp":1791296734720,"version":"4.1.0"},"reference-count":6,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,4,16]],"date-time":"2004-04-16T00:00:00Z","timestamp":1082073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Cutaneous leishmaniasis is a common disease in Iran, especially in the north\u2010east, central and southern parts of the country. Many treatments have been suggested for this disease but none is completely effective and without side\u2010effects such as pain, arthralgia and renal or cardiac complications. Lasers have been used for treatment of several skin diseases since 1970, and CO<jats:sub>2<\/jats:sub> lasers are now being used for treatment of leishmaniasis. In this study, a CO<jats:sub>2<\/jats:sub> laser (Sonic 500 machine) was used as a source of a continuous CO<jats:sub>2<\/jats:sub> laser wave.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A total of 123 patients (68 female and 55 male) with 183 lesions were treated with the CO<jats:sub>2<\/jats:sub> laser. The maximum power was 100\u00a0W and the pulse width was 0.5\u20135\u00a0s. For the control group, 110 patients (with 250 lesions) were treated with glucantime 50\u00a0mg\/kg\/day for 15\u00a0days and, after 15\u00a0days of rest, this treatment was repeated (Glucantime Amps, 1.5\u00a0g in a 50\u2010mL solution, was used). For follow\u2010up, the patients were visited 1, 3, 4, 8, 12 and 24\u00a0weeks after treatment and any complications, recurrences or other wound characteristics were recorded. In the second group, Finally, all collected data were analyzed statistically.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Statistical analysis with the \u03c7<jats:sup>2<\/jats:sup> test showed that treatment with the CO<jats:sub>2<\/jats:sub> laser was more effective than treatment with glucantime (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0007). Complications were also seen less often with the laser treatment than with glucantime and were limited to the ulcer site. The CO<jats:sub>2<\/jats:sub> laser was more effective in treating cutaneous leishmaniasis than glucantime (1.12 times), had fewer side\u2010effects (4.5% vs. 24%) and resulted in a shorter healing time (1\u00a0month vs. 3\u00a0months), and treatment could be applied in a single session.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The results of this and previous studies suggest that cutaneous leishmaniasis can be treated effectively with CO<jats:sub>2<\/jats:sub> laser if those providing the treatment are sufficiently experienced. Laser treatment is more cost\u2010effective than other treatments and can be used as first\u2010line therapy for cutaneous leishmaniasis (wet and dry types).<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02349.x","type":"journal-article","created":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T15:13:47Z","timestamp":1097162027000},"page":"736-738","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Evaluation of CO<sub>2<\/sub> laser efficacy in the treatment of cutaneous leishmaniasis"],"prefix":"10.1111","volume":"43","author":[{"given":"A.","family":"Asilian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sharif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Faghihi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sh.","family":"Enshaeieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Shariati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H.","family":"Siadat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,4,16]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"162","volume-title":"Research on Control Strategies for Leishmaniasis","author":"Nadir A","year":"1988"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1995.53.648"},{"key":"e_1_2_6_4_2","first-page":"549","article-title":"Experiences with vaccines of cutaneous leishmaniasis of mice and man","volume":"97","author":"Modabber F","year":"1989","journal-title":"Parasitology"},{"key":"e_1_2_6_5_2","first-page":"417","volume-title":"Clinic in Dermatology.","author":"Desjeux P","year":"1996"},{"key":"e_1_2_6_6_2","first-page":"103","article-title":"Treatment of C.L using a CO2 laser","volume":"69","author":"Babajev KB","journal-title":"Bulletin WHO"},{"key":"e_1_2_6_7_2","first-page":"197","article-title":"The successful treatment of CL with CO2 laser","volume":"42","author":"Redrigves AP","year":"1990","journal-title":"Rev Ubband Med"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2004.02349.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2004.02349.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T08:53:16Z","timestamp":1696927996000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2004.02349.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,16]]},"references-count":6,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["10.1111\/j.1365-4632.2004.02349.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2004.02349.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,16]]},"assertion":[{"value":"2004-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}