{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:14:20Z","timestamp":1760044460181},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,5,20]],"date-time":"2004-05-20T00:00:00Z","timestamp":1085011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p>An 80\u2010year\u2010old man presented with multiple erythematous papules on the trunk and extremities of a few weeks\u2019 duration. He had no past medical or family history of skin diseases or any other medical diseases. A biopsy showed a perivascular lymphohistiocytic infiltrate and sparse neutrophils with several atypical lymphocytes in the deeper dermis. With an initial diagnosis of T\u2010cell pseudolymphoma or unspecified neutrophilic dermatosis, he showed a brisk response to an intramuscular injection of triamcinolone acetonide (40\u00a0mg\/mL). After 1\u00a0month, his skin lesion recurred. Steroid was given with a good clinical response.<\/jats:p><jats:p>One month later, however, his skin lesion relapsed. At this time, he presented with disseminated pustulopapular lesions on the trunk and extremities. Examination revealed multiple, variable\u2010sized, erythematous plaques with central pustules on the extremities (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f1\">Fig.\u00a01<\/jats:ext-link>). The mucous membranes were not involved. He had no pain or tenderness. He had no systemic symptoms. Laboratory tests showed a hemoglobin level of 10.3\u00a0g\/dL, a leukocyte level of 6900\/mm<jats:sup>3<\/jats:sup>, with an increased proportion of segmented nuclear neutrophils (83%), and an elevated C\u2010reactive protein. A skin biopsy revealed a dense perivascular and interstitial infiltrate composed of neutrophils with marked dermal edema (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f2\">Fig.\u00a02<\/jats:ext-link>). Sweet\u2019s syndrome was the final diagnosis and he was treated with oral prednisolone (30\u201340\u00a0mg\/day) and dapsone (50\u00a0mg\/day) for 2\u00a0months.<\/jats:p><jats:p><jats:fig><jats:caption><jats:p>Multiple, variable\u2010sized, erythematous plaques with central pustules on the right arm<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:00119059:media:IJD2376:IJD_2376_f1\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p><jats:fig><jats:caption><jats:p>Dense perivascular and interstitial infiltrate composed of neutrophils in the dermis (hematoxylin and eosin, \u00d740; inset, \u00d7400)<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:00119059:media:IJD2376:IJD_2376_f2\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p>As this 80\u2010year\u2010old patient had a recurrent history of similar skin lesions and anemia, an underlying hematologic malignancy was suspected. A bone marrow biopsy showed typical myelodysplastic syndrome (MDS). The hemoglobin level was decreased to 5.3\u00a0g\/dL during a follow\u2010up period of 5\u00a0months. The skin lesions recurred despite oral steroids and dapsone. The patient received only symptomatic treatment, such as a transfusion, for the underlying malignancy MDS.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02376.x","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T08:29:58Z","timestamp":1144225798000},"page":"457-459","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A case of recurrent Sweet\u2019s syndrome in an 80\u2010year\u2010old man: a clue to an underlying malignancy"],"prefix":"10.1111","volume":"45","author":[{"given":"Hye\u2010Jin","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Eun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi\u2010Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jee\u2010Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee\u2010Chan","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jai\u2010Kyoung","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,5]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1964.tb14541.x"},{"key":"e_1_2_2_3_2","first-page":"167","article-title":"Diagnostic criteria for Sweet\u2019s syndrome","volume":"37","author":"Su WPD","year":"1986","journal-title":"Cutis"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70215-2"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1997.tb03796.x"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.12.1887"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90229-4"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00844.x"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(02)70221-1"},{"key":"e_1_2_2_10_2","unstructured":"CohenPR.Sweet\u2019s syndrome.Orphanet EncyclopediaOctober 2003.http:\/\/www.orpha.net\/data\/patho\/GB\/uk\u2010Sweet.pdf"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01891.x"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2004.02376.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2004.02376.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:40:49Z","timestamp":1696898449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2004.02376.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1111\/j.1365-4632.2004.02376.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2004.02376.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"2006-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}