{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:19:13Z","timestamp":1783703953298,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,8,24]],"date-time":"2004-08-24T00:00:00Z","timestamp":1093305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Vitiligo is an acquired depigmentary disorder of the skin and hair which results from selective destruction of melanocytes. Serological typing and genotyping of human leukocyte antigen (HLA) have shown discrepancies in HLA associations with vitiligo in different ethnic populations.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Polymerase chain reaction sequence\u2010specific primer (PCR\u2010SSP) method was used to analyze the distribution of HLA\u2010DQA<jats:sub>1<\/jats:sub> and \u2010DQB<jats:sub>1<\/jats:sub> alleles among 187 patients with vitiligo and 273 healthy controls through Epi Info version 6 package (Centers for Disease Control and Prevention, Atlanta, GA, USA).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The frequencies of HLA\u2010DQA1*0302 (OR\u00a0=\u00a01.98, <jats:italic>P<jats:sub>c<\/jats:sub><\/jats:italic>\u00a0&lt;\u00a00.01), \u2010DQB1*0303 (OR\u00a0=\u00a03.14, <jats:italic>P<jats:sub>c<\/jats:sub><\/jats:italic>\u00a0&lt;\u00a00.001), and \u2010DQB1*0503 (OR\u00a0=\u00a03.36, <jats:italic>P<jats:sub>c<\/jats:sub><\/jats:italic>\u00a0&lt;\u00a00.05) alleles were significantly increased in patients with vitiligo compared with controls, and HLA\u2010DQA<jats:sub>1<\/jats:sub>*0501 (OR\u00a0=\u00a00.40, <jats:italic>P<jats:sub>c<\/jats:sub><\/jats:italic>\u00a0&lt;\u00a00.01) allele frequency was highly decreased. HLA\u2010DQA1*0302 (OR\u00a0=\u00a05.19, <jats:italic>P<jats:sub>c<\/jats:sub><\/jats:italic>\u00a0&lt;\u00a00.001), \u2010DQA1*0601 (OR\u00a0=\u00a02.95, <jats:italic>P<jats:sub>c<\/jats:sub><\/jats:italic>\u00a0&lt;\u00a00.05), \u2010DQB1*0303 (OR\u00a0=\u00a04.50, <jats:italic>P<jats:sub>c<\/jats:sub><\/jats:italic>\u00a0&lt;\u00a00.001), and \u2010DQB1*0503 (OR\u00a0=\u00a06.69, <jats:italic>P<jats:sub>c<\/jats:sub><\/jats:italic>\u00a0&lt;\u00a00.001) alleles were positively associated, whereas HLA\u2010DQA1*0501 (OR\u00a0=\u00a00.05, <jats:italic>P<jats:sub>c<\/jats:sub><\/jats:italic>\u00a0&lt;\u00a00.001) allele was negatively associated with childhood vitiligo patients, and HLA\u2010DQB1*0303 (OR\u00a0=\u00a02.76, <jats:italic>P<jats:sub>c<\/jats:sub><\/jats:italic>\u00a0&lt;\u00a00.001) allele was positively associated with adult vitiligo patients compared with controls. The frequency of HLA\u2010DQB1*0303 (OR\u00a0=\u00a03.72, <jats:italic>P<jats:sub>c<\/jats:sub><\/jats:italic>\u00a0&lt;\u00a00.001) allele was significantly increased in localized vitiligo patients vs. controls, whereas HLA\u2010DQA1*0302 (OR\u00a0=\u00a02.47, <jats:italic>P<jats:sub>c<\/jats:sub><\/jats:italic>\u00a0&lt;\u00a00.01), \u2010DQB1*0303 (OR\u00a0=\u00a02.67, <jats:italic>P<jats:sub>c<\/jats:sub><\/jats:italic>\u00a0&lt;\u00a00.01), and \u2010DQB1*0503 (OR\u00a0=\u00a04.46, <jats:italic>P<jats:sub>c<\/jats:sub><\/jats:italic>\u00a0&lt;\u00a00.01) allele frequencies were significantly increased and \u2010DQA1*0501 (OR\u00a0=\u00a00.27, <jats:italic>P<jats:sub>c<\/jats:sub><\/jats:italic>\u00a0&lt;\u00a00.01) allele frequency was highly decreased in generalized vitiligo patients.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> HLA\u2010DQA1*0302, \u2010DQA1*0601, \u2010DQB1*0303, and \u2010DQB1*0503 alleles could be susceptible alleles of vitiligo, while HLA\u2010DQA1*0501 allele could be a protective allele in Chinese Hans. There may be different genetic backgrounds between vitiligo patients of childhood and adult, localized and generalized.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02389.x","type":"journal-article","created":{"date-parts":[[2005,12,15]],"date-time":"2005-12-15T16:39:28Z","timestamp":1134664768000},"page":"1022-1027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Association of HLA\u2010DQA1 and DQB1 genes with vitiligo in Chinese Hans"],"prefix":"10.1111","volume":"44","author":[{"given":"Sen","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Sheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang\u2010Dan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping\u2010Ping","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang\u2010Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An\u2010Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Hua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zai\u2010Xing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,8,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214643"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/9780470760116.ch6","volume-title":"Vitiligo","author":"Hann SK","year":"2000"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00032.x"},{"key":"e_1_2_6_5_2","first-page":"145","article-title":"Epidemiological study of vitiligo in Surat area, South Gujarat","volume":"61","author":"Mehta NR","year":"1973","journal-title":"Indian J Med Res"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2340\/0001555563249251","article-title":"The genetics of vitiligo","volume":"63","author":"Hafez M","year":"1983","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1177\/003693308302800405","article-title":"A family study of vitiligo patterns","volume":"28","author":"Goudie BM","year":"1983","journal-title":"Scott Med J"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370020303"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680290066010"},{"key":"e_1_2_6_10_2","first-page":"119","article-title":"A genetical model for vitiligo","volume":"43","author":"Majumder PP","year":"1988","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_11_2","first-page":"981","article-title":"Genetic epidemiology of vitiligo: multilocus recessivity cross\u2010validated","volume":"55","author":"Nath SK","year":"1994","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2001.140608.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04288.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.6.661"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)80279-5"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1001\/archderm.1990.01670250062009","article-title":"Vitiligo is associated with HLA\u2010DR4 in black patients. 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