{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:46:49Z","timestamp":1761630409403},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,8,24]],"date-time":"2004-08-24T00:00:00Z","timestamp":1093305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p>A 71\u2010year\u2010old Korean man presented with a solitary erythematous plaque on his forehead (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f1\">Fig.\u00a01<\/jats:ext-link>). It was first noticed by the patient 1\u00a0year previously and had slowly increased in size over that time. Physical examination revealed a slightly elevated, 1.5\u00a0cm\u00a0\u00d7\u00a01.5\u00a0cm erythematous plaque on the upper midline of the forehead. Sweating was not evoked by physical work or emotional stress. There was no pain or tenderness associated with the lesion. The patient had no history of trauma to the forehead. Histopathologic examination of the lesion showed increased numbers of eccrine glands, as well as dilated vascular channels in the deep dermis and subcutaneous tissue (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f2\">Fig.\u00a02<\/jats:ext-link>). An immunohistochemical study showed that these eccrine glands stained positively for S\u2010100 and carcinoembryonic antigen (CEA), and the vascular channels for the antifactor VIII\u2010related antigens. These findings are consistent with eccrine angiomatous hamartoma. There was no change in the lesion during the 1\u2010year follow\u2010up period.<\/jats:p><jats:p><jats:fig><jats:caption><jats:p>Asymptomatic erythematous plaque on the upper midline of the forehead<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:00119059:media:IJD2397:IJD_2397_f1\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p><jats:fig><jats:caption><jats:p>Increased numbers of eccrine glands and dilated vascular channels in the deep dermis and subcutaneous tissue (hematoxylin and eosin, \u00d740)<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:00119059:media:IJD2397:IJD_2397_f2\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02397.x","type":"journal-article","created":{"date-parts":[[2006,4,28]],"date-time":"2006-04-28T09:49:10Z","timestamp":1146217750000},"page":"598-599","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Late\u2010onset eccrine angiomatous hamartoma on the forehead"],"prefix":"10.1111","volume":"45","author":[{"given":"Eugene","family":"Jeong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Jeong","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sin Taik","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun 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