{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:14:47Z","timestamp":1776773687035,"version":"3.51.2"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,7,9]],"date-time":"2004-07-09T00:00:00Z","timestamp":1089331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p>A 69\u2010year\u2010old woman with a history of hypertension and essential tremor was diagnosed with a Burkitt\u2010like diffuse large\u2010cell lymphoma. She received chemotherapy with cyclophosphamide, vincristine and adriamycin (HyperCVAD). Ten days after starting the second cycle of chemotherapy (HyperCVAD), she presented with well\u2010defined, intense, erythematous macules which coalesced to form a symmetric diffuse erythema located on the upper back. Later, the lesions progressed and affected the lower back and perineal areas, extending to the groin. In a few days, a gradual diminution of the erythema was seen, with subsequent development of postinflammatory gray\u2010brownish hyperpigmentation. On the lower back, there were also superficial erosions. Some asymptomatic, closely grouped, gray papules, vesicles, and blisters were found in the groin, resembling the typical lesions of herpetic infection (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f1\">Fig.\u00a01<\/jats:ext-link>). Two biopsies of the groin and one of the upper back were performed, and were processed for histopathologic and microbiologic study.<\/jats:p><jats:p><jats:fig><jats:caption><jats:p>Closely grouped gray papules, vesicles, and blisters on the groin mimicking a herpetic infection<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:00119059:media:IJD2440:IJD_2440_f1\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p>The histopathologic study showed epidermal hyperplasia with acanthosis and papillomatosis. In both biopsies, eccrine ducts covered by mature squamous epithelium were found in the reticular dermis (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f2\">Fig.\u00a02a\u2212c<\/jats:ext-link>). In the sample from the groin, an intracorneal bulla was found. Numerous normal isolated cornified cells were seen within the lumen of the bulla (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f2\">Fig.\u00a02d<\/jats:ext-link>). An inflammatory mononuclear infiltrate was also present in a periductal and perivascular distribution. No multinucleation, ground\u2010glass nuclei, or peripheral margination of chromatin were found. Therefore, no morphologic evidence of herpes virus infection was present.<\/jats:p><jats:p><jats:fig><jats:caption><jats:p>Low (a), medium (b), and high (c) magnification showing epidermal hyperplasia and squamous syringometaplasia involving dermal eccrine ducts. (d) Medium power magnification of the intracorneal bulla (hematoxylin and eosin staining; a, \u00d740; b, \u00d7100; c, \u00d7400; d, \u00d7100)<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:00119059:media:IJD2440:IJD_2440_f2\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p>Cultures and serologic analyses for herpes simplex virus (HSV) 1 and 2, varicella zoster virus (VZV), and cytomegalovirus (CMV) were negative. The lesions were treated with topical corticosteroids, with a good response in a few days.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02440.x","type":"journal-article","created":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T16:19:31Z","timestamp":1149005971000},"page":"762-763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Eccrine squamous syringometaplasia mimicking a herpetic infection"],"prefix":"10.1111","volume":"45","author":[{"given":"Vicent","family":"Alonso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Ram\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Monteagudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Llombart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esperanza","family":"Jord\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,22]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1979.tb01136.x"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1993.tb01251.x"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199004000-00004"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660330113022"},{"key":"e_1_2_2_6_2","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1001\/archderm.1997.03890430089012","article-title":"Chemotherapy\u2010induced eccrine squamous syringometaplasia","volume":"133","author":"Valks R","year":"1997","journal-title":"Arch Dermatol"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1997.tb00817.x"},{"key":"e_1_2_2_8_2","first-page":"163","article-title":"Subtle clue to the diagnosis of the herpes virus by light microscopy. 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