{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:51:55Z","timestamp":1762541515434},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,8,24]],"date-time":"2004-08-24T00:00:00Z","timestamp":1093305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Prodromal bullous pemphigoid (PBP) can be difficult to diagnose. Early recognition in its early stages may decrease the morbidity and progression of the disease. Clinical presentations and current treatments available for PBP will be described.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A retrospective review was performed on 53 patients diagnosed with PBP.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Overall, the average disease duration of PBP was 11.8\u00a0months. The average age of presentation of PBP was 70.8\u00a0years. The most common presentations were urticaria\u2010like plaques (67.9%), eczema\u2010like lesions (11.3%), and dermatitis herpetiformis\u2010like lesions (9.4%). The majority of patients responded well to low doses of systemic corticosteroids, tetracycline, and\/or high potency topical corticosteroids.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Patients with PBP tend to be in their sixth or early seventh decade of life and, on average, the duration of disease is 1\u00a0year. The most common presentation of disease is urticaria\u2010like plaques.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02457.x","type":"journal-article","created":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T16:42:58Z","timestamp":1141058578000},"page":"209-214","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Prodromal bullous pemphigoid"],"prefix":"10.1111","volume":"45","author":[{"given":"Philina M.","family":"Lamb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Abell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Tharp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Frye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jau\u2010Shyong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1001\/archderm.1976.01630340020005","article-title":"Vesicular pemphigoid","volume":"112","author":"Bean SF","year":"1976","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2340\/0001555561417421","article-title":"Clinical variations in bullous pemphigoid with respect to early symptoms","volume":"61","author":"Asbrink E","year":"1981","journal-title":"Acta Dermatol Venereol (Stockh)"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.9.1137"},{"key":"e_1_2_5_5_2","first-page":"508","article-title":"Bullous pemphigoid presenting as generalized pruritus: observations in six patients","volume":"37","author":"Alonso\u2010Llamazares J","year":"1998","journal-title":"Int J Dermatol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1983.tb07090.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70179-W"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1992.tb02699.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1988.tb02405.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1979.04010030028010"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000249505"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70077-X"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70305-4"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1979.04010040024008"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.117.1.56"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70358-5"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb06935.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80855-9"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)80364-2"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70120-2"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)70036-8"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.4.465"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.7.903"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1979.tb15095.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011592"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200207113470215"},{"key":"e_1_2_5_27_2","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1001\/archderm.1986.01660180076019","article-title":"The treatment of bullous pemphigoid with tetracycline and niacinamide","volume":"122","author":"Berk MA","year":"1986","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70336-0"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200201313460513"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70305-3"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.3.385"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.6581643.x"},{"key":"e_1_2_5_33_2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2340\/0001555564243246","article-title":"Serum IgE levels in patients with bullous pemphigoid and its correlation to the activity of the disease and anti\u2010basement membrane zone antibodies","volume":"64","author":"Asbrink E","year":"1984","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70085-T"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2004.02457.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2004.02457.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T01:14:52Z","timestamp":1696900492000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2004.02457.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,20]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1111\/j.1365-4632.2004.02457.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2004.02457.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,20]]},"assertion":[{"value":"2006-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}