{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T18:43:40Z","timestamp":1775155420778,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,6]],"date-time":"2004-10-06T00:00:00Z","timestamp":1097020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold><jats:italic>N<\/jats:italic>\u2010acetyltransferase 2 (<jats:italic>NAT<\/jats:italic>2) polymorphism may be involved in the pathogenesis of allergic contact dermatitis.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold>The present study was designed to evaluate whether acetylation polymorphism plays a role in the susceptibility to<jats:italic>p<\/jats:italic>\u2010Phenylenediamine (PPD) sensitization.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold>The frequencies of seven<jats:italic>NAT2<\/jats:italic>point mutations, namely G191A, C282T, T341C, C481T, G590A, A803G, and G857A, and genotypes were determined by PCR\/RFLP in a total of 70 patients with allergic contact dermatitis to PPD and 100 control subjects with no history of allergy, atopy, lung disease, diabetes mellitus and cancer.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Genotypes coding rapid acetylation were detected in 52.9% and 37.0% of patients with contact dermatitis and control subjects, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). The frequency of the<jats:italic>NAT<\/jats:italic>2*4 allele and<jats:italic>NAT<\/jats:italic>2*4\/*4 genotype, coding for rapid acetylation, were also significantly higher in the contact dermatitis patients than in the control subjects (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold>Our results suggest an association between rapid acetylation polymorphism and susceptibility to PPD sensitization.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02464.x","type":"journal-article","created":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T16:42:58Z","timestamp":1141058578000},"page":"323-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Human arylamine<i>N<\/i>\u2010acetyltransferase 2 polymorphism and susceptibility to allergic contact dermatitis"],"prefix":"10.1111","volume":"45","author":[{"given":"Muradiye","family":"Nacak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zulal","family":"Erbagci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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