{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:16:06Z","timestamp":1761707766030},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,12,2]],"date-time":"2004-12-02T00:00:00Z","timestamp":1101945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2005,3]]},"abstract":"A 37\u2010year\u2010old woman with a personal history of appendicectomy, cholecystectomy, left oophorectomy secondary to an ovarian cyst complication, nephritic colic with repeated episodes of pyelonephritis, alcoholic hepatopathy, Raynaud's phenomenon and bilateral exophthalmos showed an increase in volume in the root of the upper limbs and in the base of the neck over a period of 4\u00a0years, painful to the touch and of a soft consistency. She presented with a pseudo\u2010athletic appearance (Fig.\u00a01<\/jats:ext-link>) produced by an increase in the volume at the root of the upper limbs, upper back and the back of the neck (Fig.\u00a02<\/jats:ext-link>). The lesions produced a pulling sensation and were associated with paresthesia, hyperesthesia, and a moderate loss of strength in both arms. A biopsy taken from the upper third of the right arm showed a diffuse proliferation of the subcutaneous adipose tissue, which appeared normal, and extended between the collagen fibers, reaching in some cases into the most superficial zones of the reticular dermis (Fig.\u00a03<\/jats:ext-link>). Laboratory evaluation revealed a chronic anemia, leukopenia with moderate lymphopenia, increased erythrocyte sedimentation rate, elevation of enzymes of hepatic function, decrease in total proteins, and increase in ferritin, all in the context of hepatopathy. Antinuclear antibodies and the hormonal profile were normal. Abdominal and gynecologic echography revealed a right ovarian cyst of no clinical relevance. Cranial nuclear magnetic resonance (NMR) revealed an increase in the periorbital fat responsible for bilateral exophthalmos.<\/jats:p>Pseudo\u2010athletic appearance produced by the increase in volume at the root of the upper limbs<\/jats:p><\/jats:caption>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p>Increased volume in the upper back and the back of the neck<\/jats:p><\/jats:caption>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p>Diffuse proliferation of subcutaneous cellular tissue, with normal and mature cellularity, infiltrating through the collagen fibers (Hematoxiline\/Eosine \u00d7100)<\/jats:p><\/jats:caption>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02489.x","type":"journal-article","created":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T14:54:59Z","timestamp":1110293699000},"page":"236-237","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Benign symmetric lipomatosis (Launois\u2013Bensaude syndrome)"],"prefix":"10.1111","volume":"44","author":[{"given":"Jos\u00e9","family":"Fern\u00e1ndez\u2010Vozmediano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Armario\u2010Hita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12,2]]},"reference":[{"key":"e_1_2_2_2_2","first-page":"298","article-title":"De l\u2019ad\u00e9no\u2010lipomatose sym\u00e9trique","volume":"1","author":"Launois PE","year":"1898","journal-title":"Bull Soc Med H\u00f4p Paris"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(74)90043-2"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197209000-00030"},{"key":"e_1_2_2_5_2","first-page":"31","article-title":"Lipomatosis Launois\u2013Bensaude bei Morbus Recklinghausen","volume":"8","author":"Garnier C","year":"1982","journal-title":"Akt Dermatol"},{"key":"e_1_2_2_6_2","first-page":"1","article-title":"Die benigne symmetrische Lipomatose: ein Symptom der \u00e4thylischen Hepatopathie?","volume":"109","author":"H\u00e4uptli W","year":"1979","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108881"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70253-9"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70052-3"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2004.02489.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2004.02489.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T22:39:05Z","timestamp":1697323145000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2004.02489.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,2]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["10.1111\/j.1365-4632.2004.02489.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2004.02489.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,2]]},"assertion":[{"value":"2004-12-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}