{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:16:21Z","timestamp":1763036181362},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,7,28]],"date-time":"2006-07-28T00:00:00Z","timestamp":1154044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>A female child, a product of a nonconsanguineous parentage and normal pregnancy, was seen first at the age of 4\u00a0years. She had suffered from recurrent episodes of multiple, erythematous, confluent plaques and a few bullous lesions all over the body since infancy. The child was irritable but had no history of flushing, dyspnea, wheezing, or frequent diarrhea. Darier's sign was strongly positive and systemic examination did not reveal any abnormality. Routine laboratory investigations were normal and a skin biopsy specimen revealed an unremarkable epidermis and dense proliferation of round to spindle\u2010shaped mast cells which stained positive for metachromatic granules (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f1\">Fig.\u00a01<\/jats:ext-link>). With the diagnosis of urticaria pigmentosa, she was managed with antihistaminic drugs and the parents were advised to handle the child gently. She did not report for further follow\u2010up.<\/jats:p><jats:p><jats:fig><jats:caption><jats:p>Photomicrograph of skin histology showing metachromatic granules (toluidine blue, \u00d740)<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:00119059:media:IJD2493:IJD_2493_f1\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p>Recently, the child, now 8\u00a0years of age, was brought again with finely wrinkled, lax, and redundant skin, especially of the face, giving her a senile appearance (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f2\">Fig.\u00a02<\/jats:ext-link>). Systemic examination did not show any abnormality. History revealed that the child had been asymptomatic during the last 4\u00a0years even without treatment, but developed slowly progressive lax and pendulous skin. A repeat biopsy from the lax facial skin revealed sparse and fragmented elastic fibres, normal collagen, and a perivascular and intradermal cellular infiltrate composed of metachromatic mast cells. Her serum \u03b1<jats:sub>1<\/jats:sub>\u2010antitrypsin levels were 190.0\u00a0mg\/dL (normal, 93\u2013224\u00a0mg\/dL) and a pulmonary function test showed no abnormality. Treatment with antihistaminic drugs was started again and she was advised to have a cosmetic facial uplift at a later stage.<\/jats:p><jats:p><jats:fig><jats:caption><jats:p>Patient with urticaria pigmentosa seen at 8\u00a0years of age showing cutis laxa and a senile appearance<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:00119059:media:IJD2493:IJD_2493_f2\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02493.x","type":"journal-article","created":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T08:43:39Z","timestamp":1154940219000},"page":"949-951","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cutis laxa acquisita associated with cutaneous mastocytosis"],"prefix":"10.1111","volume":"45","author":[{"given":"Vikram K.","family":"Mahajan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nand Lal","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geeta","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,28]]},"reference":[{"key":"e_1_2_3_2_2","first-page":"2019","volume-title":"Textbook of Dermatology","author":"Burton JL","year":"1998"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70252-O"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2002.00579.x"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.117394"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199610000-00013"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-950.x"},{"key":"e_1_2_3_8_2","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1046\/j.1365-4362.1997.00253.x","article-title":"Acquired cutis laxa associated with cutaneous angiocentric T\u2010cell lymphoma","volume":"36","author":"Chartier S","year":"1997","journal-title":"Int J Dermatol"},{"key":"e_1_2_3_9_2","first-page":"561","article-title":"Cutis laxa acquisita: is there any association with Borrelia burgdorferi?","volume":"9","author":"Ozkan S","year":"1999","journal-title":"Eur J Dermatol"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1985.tb00466.x"},{"key":"e_1_2_3_11_2","first-page":"2065","volume-title":"Textbook of Dermatology","author":"Greaves MW","year":"1998"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70005-3"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1996.tb06340.x"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12277389"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90431-X"},{"key":"e_1_2_3_16_2","first-page":"537","article-title":"Characterisation and partial purification of a neutral protease from the serum of a patient with autosomal recessive pulmonary emphysema and cutis laxa","volume":"105","author":"Anderson LL","year":"1985","journal-title":"J Lab Clin Med"},{"key":"e_1_2_3_17_2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1001\/archderm.1965.01600160029006","article-title":"Cutis laxa","volume":"92","author":"Goltz RW","year":"1965","journal-title":"Arch Dermatol"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2004.02493.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2004.02493.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T21:43:38Z","timestamp":1707169418000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2004.02493.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,28]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1365-4632.2004.02493.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2004.02493.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,28]]},"assertion":[{"value":"2006-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}