{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:40:39Z","timestamp":1769085639775,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":1154,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Neoplasia\u2010induced lichen planus is described as a cell\u2010mediated reaction to unknown epithelial antigens. Paraneoplastic pemphigus (PNP), characterized by the presence of a specific array of autoantibodies, probably represents a different form of presentation of the same autoimmune syndrome where the mucocutaneous expression depends on the dominant pathologic mechanism.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> The authors report a case of PNP with predominant lichen planus\u2010like lesions and review the relevant literature. We observed a 74\u2010year\u2010old female with vesico\u2010bullous, erosive, target\u2010shaped and flat papular lichenoid lesions on the lower legs, palms and soles, evolving for 3\u00a0weeks. Histopathology revealed a lichenoid dermatitis. Direct immunofluorescence showed C3 deposition around keratinocytes and epidermal IgG intranuclear deposition. Indirect immunofluorescence revealed circulating IgG with intercellular staining on rat bladder substrate. Immunoblotting demonstrated bands of 130, 190, 210 and 250\u00a0kDa antigens. A pararenal B cell lymphoma was found.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Oral corticotherapy with 40\u00a0mg prednisolone daily was initiated with a good cutaneous response. Four months later, cyclophosphamide (50\u00a0mg\/day) was introduced because of a discrete enlargement of the pararenal mass. The patient died on the seventh month of follow up as a result of respiratory insufficiency.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> PNP has different forms of presentation and the lack of a consensus about diagnostic criteria may contribute to underdiagnosed cases. Advances on the knowledge of the sensitivity and specificity of diagnostic criteria have allowed a better accuracy of diagnosis.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02526.x","type":"journal-article","created":{"date-parts":[[2005,5,3]],"date-time":"2005-05-03T09:04:50Z","timestamp":1115111090000},"page":"366-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Paraneoplastic pemphigus with clinical features of lichen planus associated with low\u2010grade B cell lymphoma"],"prefix":"10.1111","volume":"44","author":[{"given":"S\u00f3nia","family":"Coelho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 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